Abstract
Determination of the complete sequences of echovirus 12 and a rhodanine-resistant variant revealed seven amino acid deviations and two additional exchanges not confirmed in all clones. In rhodanine sensitivity assays with infectious cDNAs, it was shown that the biological markers of the original viruses are maintained.
Full Text
The Full Text of this article is available as a PDF (454.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chapman M. S., Minor I., Rossmann M. G., Diana G. D., Andries K. Human rhinovirus 14 complexed with antiviral compound R 61837. J Mol Biol. 1991 Feb 5;217(3):455–463. doi: 10.1016/0022-2836(91)90749-v. [DOI] [PubMed] [Google Scholar]
- Eggers H. J., Koch M. A., Furst A., Daves G. D., Jr, Wilczynski J. J., Folkers K. Rhodanine: a selective inhibitor of the multiplication of echovirus 12. Science. 1970 Jan 16;167(3916):294–297. doi: 10.1126/science.167.3916.294. [DOI] [PubMed] [Google Scholar]
- Eggers H. J. Selective inhibiton of uncoating of echovirus 12 by rhodanine. A study on early virus-cell interactions. Virology. 1977 May 1;78(1):241–252. doi: 10.1016/0042-6822(77)90095-2. [DOI] [PubMed] [Google Scholar]
- Smith T. J., Kremer M. J., Luo M., Vriend G., Arnold E., Kamer G., Rossmann M. G., McKinlay M. A., Diana G. D., Otto M. J. The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science. 1986 Sep 19;233(4770):1286–1293. doi: 10.1126/science.3018924. [DOI] [PubMed] [Google Scholar]
- Zimmermann A., Mertens T., Schulz A., Kruppenbacher J. P., Nelsen-Salz B., Eggers H. J. HPLC is an effective and fast method for analysis of viral proteins: a study of encephalomyocarditis virus mutants differing in pathogenicity. J Gen Virol. 1993 Dec;74(Pt 12):2759–2763. doi: 10.1099/0022-1317-74-12-2759. [DOI] [PubMed] [Google Scholar]