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. 1992 Apr;36(4):867–869. doi: 10.1128/aac.36.4.867

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.

M Arthur 1, C Molinas 1, T D Bugg 1, G D Wright 1, C T Walsh 1, P Courvalin 1
PMCID: PMC189469  PMID: 1503450

Abstract

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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