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. 1992 Apr;36(4):873–875. doi: 10.1128/aac.36.4.873

In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic.

M L Sanchez 1, R P Wenzel 1, R N Jones 1
PMCID: PMC189476  PMID: 1386973

Abstract

The in vitro activity of decaplanin (formerly M86-1410), a novel glycopeptide antimicrobial agent, was tested against 169 gram-positive bloodstream isolates from patients at the University of Iowa Hospitals and Clinics and 12 selected vancomycin-resistant strains. Enterococcus faecalis, E. faecium, Staphylococcus aureus, streptococci, bacilli, corynebacteria, and listeria were inhibited by decaplanin (MICs for 90% of the strains tested [MIC90s], 0.12 to 4 micrograms/ml). However, some rarely isolated and selected Enterococcus sp. populations had a MIC90 of 16 micrograms/ml, and S. haemolyticus strains had a MIC90 of 8 micrograms/ml. These in vitro results suggest that decaplanin may be useful against most gram-positive strains, even though some Enterococcus species and coagulase-negative staphylococci were potentially resistant (MICs, greater than or equal to 8 micrograms/ml).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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