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. 2005 Feb 8;105(10):3893–3901. doi: 10.1182/blood-2003-10-3501

Table 1.

Activation sites of pro-tryptase ε, pro-uPA, pro-tPA, and plasminogen

Zymogen processing site
Protease propeptide-P1-P1′-P2′-P3′-P4′-P5′-mature domain
Human pro-tryptase ε Arg-Val-Val-Gly-Gly-Glu
Rat pro-tryptase ε Arg-Val-Val-Gly-Gly-Glu
Mouse pro-tryptase ε Arg-Ile-Val-Gly-Gly-Glu
Mouse pro-uPA Lys-Ile-Val-Gly-Gly-Glu
Rat pro-uPA Lys-Ile-Val-Gly-Gly-Glu
Human pro-uPA Lys-Ile-Ile-Gly-Gly-Glu
Human pro-tPA Arg-Ile-Lys-Gly-Gly-Leu
Mouse pro-tPA Arg-Ile-Lys-Gly-Gly-Leu
Rat pro-tPA Arg-Ile-Lys-Gly-Gly-Leu
Human plasminogen Arg-Val-Val-Gly-Gly-Cys
Mouse plasminogen Arg-Val-Val-Gly-Gly-Cys
Rat plasminogen Arg-Val-Val-Gly-Gly-Cys
Danio rerio plasminogen Arg-Ile-Val-Gly-Gly-Cys