Table 1.
Phenotype of KPM+ mice and controls
| Genotype | pl-pC | WBC × 103 per μL (median) | Hct % (median) | Platelets per μL (median) | Spleen weight mg (median) | Liver weight mg (median) | Phenotype |
|---|---|---|---|---|---|---|---|
| KPM | + | 61-512 (181) n = 9 | 14-45 (30) n = 9 | 81-1151 (501) n = 9 | 840-2308 (1324) n = 9 | 1220-2880 (2131) n = 9 | APL* |
| KPM | + | 30-603 (211) n = 4 | 21-34 (28) n = 4 | 452-811 (563) n = 4 | 1170-1810 (1395) n = 4 | 2000-3240 (2482) n = 4 | MPD |
| KM | + | 15-111 (59) n = 18 | 9-44 (30) n = 18 | 515-1456 (891) n = 18 | 270-1690 (606) n = 19 | 790-2110 (1390) n = 19 | MPD |
| KP | + | 2.5-6.2 (4.4) n = 5 | 42-48 (45) n = 5 | 306-746 (598) n = 5 | 240-300 (268) n = 6 | 1050-1660 (1318) n = 6 | Myeloid hyperplasia (APL†) |
Normal mouse spleen weight was 70 to 130 mg. Normal mouse WBC count was 3 to 9 × 103 per μL
*
High penetrance disease with short latency
†
Low penetrance disease with long latency