Table 2.
No. patients affected/no. evaluable patients (%)
|
||
---|---|---|
Parameter | HLA-identical | HLA-nonidentical |
Early deaths, before day 21 | 5/62 (8) | 1/25 (4) |
Sustained engraftment | 56/57 (99) | 22/25 (88) |
GVHD | ||
Acute, grades II-IV | 40/57 (70) | 18/24 (75) |
Chronic* | 25/48 (52) | 12/21 (57) |
Overall survival | 38/62 (61) | 11/25 (44) |
Survival by regimen | ||
CY + ATG + TBI | ||
–3 × 200 cGy | 4/8 (50) | 2/6 (33) |
–2 × 200 cGy | 6/12 (50) | 3/6 (50) |
–1 × 200 cGy | 23/35 (66) | 5/11 (45) |
CY + TBI (6 × 200) | 5/7 (71) | 0/2 (0) |
Median follow-up was 7 years (range, 1.2-10.2 years)
Chronic GVHD requiring therapy