Table 3.
Risk of NHL in relation to variants in DNA repair genes, by repair pathway
| Variants according to gene | Cases | Controls | OR (95% CI) | P trend |
|---|---|---|---|---|
| Nonhomologous end joining/V(D)J genes | ||||
| LIG4 (T9I) | ||||
| CC | 792 | 628 | 1.0 | |
| CT | 300 | 275 | 0.9 (0.7-1.1) | |
| TT | 18 | 28 | 0.5 (0.3-0.9) | .03 |
| CT or TT | 318 | 303 | 0.8 (0.7-1.0) | |
| RAG1 (K820R) | ||||
| AA | 814 | 722 | 1.0 | |
| AG | 256 | 185 | 1.3 (1.0-1.6) | |
| GG | 35 | 15 | 2.7 (1.4-5.0) | < .001 |
| AG or GG | 291 | 200 | 1.4 (1.1-1.7) | |
| Homologous recombination repair | ||||
| BRCA2 (N372H) | ||||
| AA | 577 | 505 | 1.0 | |
| AC | 441 | 361 | 1.1 (0.9-1.3) | |
| CC | 98 | 60 | 1.5 (1.0-2.1) | .07 |
| CC or AC | 539 | 421 | 1.1 (0.9-1.3) | |
| WRN (V114I) | ||||
| GG | 652 | 533 | 1.0 | |
| GA | 86 | 91 | 0.8 (0.6-1.1) | |
| AA | 5 | 9 | 0.4 (0.1-1.3) | .04 |
| GA or AA | 91 | 100 | 0.7 (0.6-1.0) | |
| Base excision repair | ||||
| XRCC1 (R194W) | ||||
| CC | 916 | 804 | 1.0 | |
| CT | 186 | 116 | 1.4 (1.1-1.8) | |
| TT | 9 | 7 | 1.3 (0.5-3.4) | .007 |
| CT or TT | 195 | 123 | 1.4 (1.1-1.8) |
All analyses were adjusted for reference age (younger than 55 years, 55 to 64 years, 65 years or older), sex, race (White, African American, other), and study site. Participants with missing data are omitted.
OR indicates odds ratio; CI, confidence interval.