Figure 3.

Pharmacokinetics of anti-CR1/¹²⁵I-tPA and IgG/¹²⁵I-tPA in TgN-hCR1 mice versus WT mice. (A) Blood clearance of conjugates. Wild-type (WT) and TgN-hCR1 mice (CR1 TG) were injected with ¹²⁵I-tPA–containing conjugates, and percent of the injected dose (%ID) in the blood was measured. (B) Percent of ¹²⁵Iodine recovered in plasma (▪) versus RBC pellet (hatched bars) in blood obtained 1 minute, 1 hour, or 3 hours after injection of ¹²⁵I-labeled conjugates in TgN-hCR1 or WT mice. (C) Organ distribution of anti-CR1/¹²⁵I-tPA versus IgG/¹²⁵I-tPA 3 hours after injection in TgN-hCR1 and WT mice. (The number of animals in all experiments is 5 per group.)