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. 1995 Nov;69(11):7286–7290. doi: 10.1128/jvi.69.11.7286-7290.1995

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

M Rodriguez 1, K Pavelko 1, R L Coffman 1
PMCID: PMC189655  PMID: 7474155

Abstract

Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.

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Selected References

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