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. 1995 Nov;69(11):7304–7308. doi: 10.1128/jvi.69.11.7304-7308.1995

Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen.

S Laurent 1, M Bastin 1
PMCID: PMC189659  PMID: 7474159

Abstract

We introduced various elements of the polyomavirus origin of DNA replication into the genome of rat cells, and we analyzed their capacity to elicit rearrangements within the integrated sequences when exposed to large T antigen. The cis-acting sequences required for homologous recombination were those that make up a functional replication origin.

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Selected References

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