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. 1995 Dec;69(12):8035–8040. doi: 10.1128/jvi.69.12.8035-8040.1995

The coxsackievirus A9 RGD motif is not essential for virus viability.

P J Hughes 1, C Horsnell 1, T Hyypiä 1, G Stanway 1
PMCID: PMC189749  PMID: 7494317

Abstract

An RGD (arginine-glycine-aspartic acid) motif in coxsackievirus A9 has been implicated in internalization through an interaction with the integrin alpha v beta 3. We have produced a number of virus mutants, lacking the motif, which have a small-plaque phenotype in LLC-Mk2 and A-Vero cells and are phenotypically normal in RD cells. Substitution of flanking amino acids also affected plaque size. The results suggest that interaction between the RGD motif and alpha v beta 3 is not critical for virus viability in the cell lines tested and therefore that alternative regions of the CAV-9 capsid are involved in internalization.

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Selected References

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