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. 1995 Dec;69(12):8147–8150. doi: 10.1128/jvi.69.12.8147-8150.1995

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.

L Ozmen 1, M Aguet 1, G Trinchieri 1, G Garotta 1
PMCID: PMC189771  PMID: 7494339

Abstract

The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.

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Selected References

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