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. 1964 May;57(5):377–384. doi: 10.1177/003591576405700516

Studies of Folate Deficiency in Man

Victor Herbert
PMCID: PMC1897956  PMID: 14168843

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARAKAWA T., OHARA K., KUDO Z., TADA K., HAYASHI T., MIZUNO T. "HYPERFOLIC-ACIDEMIA WITH FORMIMINOGLUTAMIC-ACIDURIA FOLLOWING HISTIDINE LOADING". SUGGESTED FOR A CASE OF CONGENITAL DEFICIENCY IN FORMIMINOTRANSFERASE. Tohoku J Exp Med. 1963 Sep 25;80:370–382. [PubMed] [Google Scholar]
  2. ARDEMAN S., CHANARIN I., FRANKLAND A. W. THE PELGER-HUUET ANOMALY AND MEGALOBLASTIC ANEMIA. Blood. 1963 Oct;22:472–476. [PubMed] [Google Scholar]
  3. BAKER H., HERBERT V., FRANK O., PASHER I., HUTNER S. H., WASSERMAN L. R., SOBOTKA H. A microbiologic method for detecting folic acid deficiency in man. Clin Chem. 1959 Aug;5(4):275–280. [PubMed] [Google Scholar]
  4. BARBIER F. Un cas particulier d'hypersegmentation constitutionnelle des noyaux des neutrophiles chez l'homme. Acta Haematol. 1958 Feb;19(2):121–125. doi: 10.1159/000205421. [DOI] [PubMed] [Google Scholar]
  5. BUTTERWORTH C. E., Jr, PEREZ-SANTIAGO E. Jejunal biopsies in sprue. Ann Intern Med. 1958 Jan;48(1):8–29. doi: 10.7326/0003-4819-48-1-8. [DOI] [PubMed] [Google Scholar]
  6. CHANARIN I., MOLLIN D. L., ANDERSON B. B. Folic acid deficiency and the megaloblastic anaemias. Proc R Soc Med. 1958 Sep;51(9):757–763. doi: 10.1177/003591575805100916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. COOKE W. T., FONE D. J., COX E. V., MEYNELL M. J., GADDIE R. ACUTE FOLIC ACID DEFICIENCY OF UNKNOWN AETIOLOGY: TEMPERATE SPRUE. Gut. 1963 Sep;4:292–298. doi: 10.1136/gut.4.3.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. COOPER B. A., LOWENSTEIN L. Evaluation of assessment of folic-acid deficiency by serum folic-acid activity measured with L. casei. Can Med Assoc J. 1961 Oct 28;85:987–988. [PMC free article] [PubMed] [Google Scholar]
  9. COX E. V., MEYNELL M. J., COOKE W. T., GADDIE R. Folic acid activity during blood regeneration. Clin Sci. 1960 May;19:219–228. [PubMed] [Google Scholar]
  10. DAVIS R. E., KELLY A. The microbiological assay of serum folic acid activity. Aust J Exp Biol Med Sci. 1962 Dec;40:437–444. doi: 10.1038/icb.1962.48. [DOI] [PubMed] [Google Scholar]
  11. DAWBARN M. C., HINE D. C., SMITH J. Folic acid activity in the liver of sheep. III. The effect of vitamin B12 deficiency on the concentration of folic acid and citrovorum factor. Aust J Exp Biol Med Sci. 1958 Dec;36(6):541–545. doi: 10.1038/icb.1958.58. [DOI] [PubMed] [Google Scholar]
  12. DELMONTE L., JUKES T. H. Folic acid antagonists in cancer chemotherapy. Pharmacol Rev. 1962 Mar;14:91–135. [PubMed] [Google Scholar]
  13. DONALDSON K. O., KERESZTESY J. C. Naturally occurring forms of folic acid. I. "Prefolic A": preparation of concentrate and enzymatic conversion to citrovorum factor. J Biol Chem. 1959 Dec;234:3235–3240. [PubMed] [Google Scholar]
  14. GIRDWOOD R. H. Folic acid, its analogs and antagonists. Adv Clin Chem. 1960;3:235–297. doi: 10.1016/s0065-2423(08)60101-8. [DOI] [PubMed] [Google Scholar]
  15. GUEST J. R., FRIEDMAN S., WOODS D. D., SMITH E. L. A methyl analogue of cobamide coenzyme in relation to methionine synthesis by bacteria. Nature. 1962 Jul 28;195:340–342. doi: 10.1038/195340a0. [DOI] [PubMed] [Google Scholar]
  16. HANSEN H. A., WEINFELD A. Metabolic effects and diagnostic value of small doses of folic acid and B12 in megaloblastic anemias. Acta Med Scand. 1962 Oct;172:427–443. doi: 10.1111/j.0954-6820.1962.tb07176.x. [DOI] [PubMed] [Google Scholar]
  17. HERBERT V., BAKER H., FRANK O., PASHER I., SOBOTKA H., WASSERMAN L. R. The measurement of folic acid activity in serum: a diagnostic aid in the differentiation of the megaloblastic anemias. Blood. 1960 Feb;15:228–235. [PubMed] [Google Scholar]
  18. HERBERT V., LARRABEE A. R., BUCHANAN J. M. Studies on the identification of a folate compound of human serum. J Clin Invest. 1962 May;41:1134–1138. doi: 10.1172/JCI104565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. HERBERT V., STREIFF R. R., SULLIVAN L. W., FRIEDKIN M. FAILURE OF MENADIONE TO AFFECT FOLATE UTILIZATION IN VITAMIN B 12-DEFICIENT HUMAN BEINGS. Nature. 1964 Jan 11;201:196–197. doi: 10.1038/201196a0. [DOI] [PubMed] [Google Scholar]
  20. HERBERT V., SULLIVAN L. W. Formiminoglutamicaciduria in humans with megaloblastic anemia: diminution by methionine or glycine. Proc Soc Exp Biol Med. 1963 Feb;112:304–305. doi: 10.3181/00379727-112-28023. [DOI] [PubMed] [Google Scholar]
  21. HERBERT V., ZALUSKY R., DAVIDSON C. S. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia, and liver disease. Ann Intern Med. 1963 Jun;58:977–988. doi: 10.7326/0003-4819-58-6-977. [DOI] [PubMed] [Google Scholar]
  22. IZAK G., RACHMILEWITZ M., SADOVSKY A., BERCOVICI B., ARONOVITCH J., GROSSOWICZ N. Folic acid metabolites in whole blood and serum in anemia of pregnancy. Am J Clin Nutr. 1961 Jul-Aug;9:473–477. doi: 10.1093/ajcn/9.4.473. [DOI] [PubMed] [Google Scholar]
  23. JUKES T. H. Assay of compounds with folic acid activity. Methods Biochem Anal. 1955;2:121–151. doi: 10.1002/9780470110188.ch5. [DOI] [PubMed] [Google Scholar]
  24. LINDENBAUM J., KLIPSTEIN F. A. FOLIC ACID DEFICIENCY IN SICKLE-CELL ANEMIA. N Engl J Med. 1963 Oct 24;269:875–882. doi: 10.1056/NEJM196310242691701. [DOI] [PubMed] [Google Scholar]
  25. MARSHALL R. A., JANDL J. H. Responses to "physiologic" doses of folic acid in the megaloblastic anemias. Arch Intern Med. 1960 Mar;105:352–360. doi: 10.1001/archinte.1960.00270150006002. [DOI] [PubMed] [Google Scholar]
  26. METZ J. Folates in megaloblastic anaemia. Bull World Health Organ. 1963;28(4):517–529. [PMC free article] [PubMed] [Google Scholar]
  27. MOLLIN D. L. The megaloblastic anemias. Annu Rev Med. 1960;11:333–352. doi: 10.1146/annurev.me.11.020160.002001. [DOI] [PubMed] [Google Scholar]
  28. NORONHA J. M., ABOOBAKER V. S. Studies on the folate compounds of human blood. Arch Biochem Biophys. 1963 Jun;101:445–447. doi: 10.1016/0003-9861(63)90501-0. [DOI] [PubMed] [Google Scholar]
  29. PHILLIPS P. M., TOENNIES G., USDIN E. Precursors of the folic acid-active factors of blood. J Biol Chem. 1956 Aug;221(2):855–863. [PubMed] [Google Scholar]
  30. SCHEINDLIN S., GRIFFITH I. The action of ascorbic acid on folic acid. Am J Pharm Sci Support Public Health. 1951 Mar;123(3):78–86. [PubMed] [Google Scholar]
  31. SHEEHY T. W., RUBINI M. E., PEREZ-SANTIAGO E., SANTINI R., Jr, HADDOCK J. The effect of "minute" and "titrated" amounts of folic acid on the megaloblastic anemia of tropical sprue. Blood. 1961 Dec;18:623–636. [PubMed] [Google Scholar]
  32. SMITH E. L., MERVYN L., JOHNSON A. W., SHAW N. Partial synthesis of vitamin B 12 coenzymes and analogues. Nature. 1962 Jun 23;194:1175–1175. doi: 10.1038/1941175a0. [DOI] [PubMed] [Google Scholar]
  33. UNDRITZ E. Eine neue Sippe mit erblichkonstitutioneller Hochsegmentierung der Neutrophilenkerne. Schweiz Med Wochenschr. 1958 Oct 11;88(41):1000–1001. [PubMed] [Google Scholar]
  34. VILTER R. W., WILL J. J., WRIGHT T., RULLMAN D. Interrelationships of vitamin B12, folic acid and ascorbic acid in the megaloblastic anemias. Am J Clin Nutr. 1963 Feb;12:130–144. doi: 10.1093/ajcn/12.2.130. [DOI] [PubMed] [Google Scholar]
  35. WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. WEISSBACH H., PETERKOFSKY A., REDFIELD B. G., DICKERMAN H. STUDIES ON THE TERMINAL REACTION IN THE BIOSYNTHESIS OF METHIONINE. J Biol Chem. 1963 Oct;238:3318–3324. [PubMed] [Google Scholar]
  37. WITTS L. J. Some aspects of the pathology of anaemia. I. Theory of maturation arrest. Br Med J. 1961 Aug 5;2(5248):325–328. doi: 10.1136/bmj.2.5248.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. ZALUSKY R., HERBERT V., CASTLE W. B. Cyanocobalamin therapy effect in folic acid deficiency. Arch Intern Med. 1962 May;109:545–554. doi: 10.1001/archinte.1962.03620170043007. [DOI] [PubMed] [Google Scholar]
  39. ZALUSKY R., HERBERT V. Megaloblastic anemia in scurvy with response to 50 microgm. of folic acid daily. N Engl J Med. 1961 Nov 23;265:1033–1038. doi: 10.1056/NEJM196111232652103. [DOI] [PubMed] [Google Scholar]

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