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. 1996 Jan;70(1):617–622. doi: 10.1128/jvi.70.1.617-622.1996

Vaccination protects against in vivo-grown feline immunodeficiency virus even in the absence of detectable neutralizing antibodies.

D Matteucci 1, M Pistello 1, P Mazzetti 1, S Giannecchini 1, D Del Mauro 1, L Zaccaro 1, P Bandecchi 1, F Tozzini 1, M Bendinelli 1
PMCID: PMC189855  PMID: 8523581

Abstract

So far, vaccination experiments against feline immunodeficiency virus have used in vitro-grown virus to challenge the vaccinated hosts. In this study, cats were vaccinated with fixed feline immunodeficiency virus-infected cells and challenged with plasma obtained from cats infected with the homologous virus diluted to contain 10 cat 50% infectious doses. As judged by virus culture, PCRs, and serological analyses performed over an 18-month period after the challenge, all of the vaccinated cats were clearly protected. Interestingly, prior to challenge most vaccines lacked antibodies capable of neutralizing a fresh isolate of the homologous virus.

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Selected References

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