Abstract
C57BL/6 mice are resistant to C3H mouse mammary tumor virus (MMTV)-induced mammary tumorigenesis and lack major histocompatibility complex class II I-E molecules that are essential for presentation of C3H superantigen to T cells. T cells are needed for transmission of milk-borne MMTV from the gut to the mammary gland. In this report, we show that infectious C3H MMTV is produced by C57BL/6 mice that nurse on C3H mothers but that virus production in the mammary gland is delayed compared with that in I-E+ mouse strains.
Full Text
The Full Text of this article is available as a PDF (224.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Acha-Orbea H., Shakhov A. N., Scarpellino L., Kolb E., Müller V., Vessaz-Shaw A., Fuchs R., Blöchlinger K., Rollini P., Billotte J. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Nature. 1991 Mar 21;350(6315):207–211. doi: 10.1038/350207a0. [DOI] [PubMed] [Google Scholar]
- Choi Y., Kappler J. W., Marrack P. A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus. Nature. 1991 Mar 21;350(6315):203–207. doi: 10.1038/350203a0. [DOI] [PubMed] [Google Scholar]
- Golovkina T. V., Chervonsky A., Dudley J. P., Ross S. R. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell. 1992 May 15;69(4):637–645. doi: 10.1016/0092-8674(92)90227-4. [DOI] [PubMed] [Google Scholar]
- Golovkina T. V., Dudley J. P., Jaffe A. B., Ross S. R. Mouse mammary tumor viruses with functional superantigen genes are selected during in vivo infection. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4828–4832. doi: 10.1073/pnas.92.11.4828. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Golovkina T. V., Jaffe A. B., Ross S. R. Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range. J Virol. 1994 Aug;68(8):5019–5026. doi: 10.1128/jvi.68.8.5019-5026.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Held W., Shakhov A. N., Izui S., Waanders G. A., Scarpellino L., MacDonald H. R., Acha-Orbea H. Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus. J Exp Med. 1993 Feb 1;177(2):359–366. doi: 10.1084/jem.177.2.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Held W., Waanders G. A., Shakhov A. N., Scarpellino L., Acha-Orbea H., MacDonald H. R. Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell. 1993 Aug 13;74(3):529–540. doi: 10.1016/0092-8674(93)80054-i. [DOI] [PubMed] [Google Scholar]
- Hilgers J., Bentvelzen P. Interaction between viral and genetic factors in murine mammary cancer. Adv Cancer Res. 1978;26:143–195. doi: 10.1016/s0065-230x(08)60087-1. [DOI] [PubMed] [Google Scholar]
- Karapetian O., Shakhov A. N., Kraehenbuhl J. P., Acha-Orbea H. Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model. J Exp Med. 1994 Oct 1;180(4):1511–1516. doi: 10.1084/jem.180.4.1511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kozak C., Peters G., Pauley R., Morris V., Michalides R., Dudley J., Green M., Davisson M., Prakash O., Vaidya A. A standardized nomenclature for endogenous mouse mammary tumor viruses. J Virol. 1987 May;61(5):1651–1654. doi: 10.1128/jvi.61.5.1651-1654.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Penninger J. M., Wallace V. A., Timms E., Mak T. W. Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. Eur J Immunol. 1994 May;24(5):1102–1108. doi: 10.1002/eji.1830240514. [DOI] [PubMed] [Google Scholar]
- Pucillo C., Cepeda R., Hodes R. J. Expression of a MHC class II transgene determines both superantigenicity and susceptibility to mammary tumor virus infection. J Exp Med. 1993 Oct 1;178(4):1441–1445. doi: 10.1084/jem.178.4.1441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simpson E., Dyson P. J., Knight A. M., Robinson P. J., Elliott J. I., Altmann D. M. T-cell receptor repertoire selection by mouse mammary tumor viruses and MHC molecules. Immunol Rev. 1993 Feb;131:93–115. doi: 10.1111/j.1600-065x.1993.tb01532.x. [DOI] [PubMed] [Google Scholar]
- Verstraeten A. A., Van Nie R., Kwa H. G., Hageman P. C. Quantitative estimation of mouse mammary tumor virus (MTV) antigens by radioimmunoassay;. Int J Cancer. 1975 Feb 15;15(2):270–281. doi: 10.1002/ijc.2910150213. [DOI] [PubMed] [Google Scholar]