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. 2007 Jan 12;189(6):2339–2349. doi: 10.1128/JB.01827-06

Table 2a.

        HP1315 JHP1235 0.39 Ribosomal protein, rps19 op hp1320-hp1292?
        HP1316 JHP1236 0.35 Ribosomal protein, rpl2 op hp1320-hp1292? − (39)
        HP1318 JHP1238 0.47 Ribosomal protein, rpl4 op hp1320-hp1292? − (39)
        HP1319 JHP1239 0.48 Ribosomal protein, rpl3 op hp1320-hp1292? − (39)
        HP1554 JHP1445 0.28 Ribosomal protein, rps2 op hp1454-hp1455
        HP1555 JHP1444 0.36 Translation elongation factor EF-Ts op hp1454-hp1455
    Transport and binding proteins
        HP0140 JHP0128 0.30 Predicted l-lactate permease, lctP op 0140-hp0141? − (7)
        HP0299 JHP0284 0.35 Predicted dipeptide permease protein, dppB op hp0298-hp0304 + (39), − (7)
        HP0300 JHP0285 0.37 Predicted dipeptide transport system permease protein, dppC op hp0298-hp0304 + (39)
        HP0302 JHP0287 0.35 Predicted dipeptide transport system permease protein, dppF op hp0298-hp0304 + (39)
        HP0693 JHP0635 0.24 Predicted short-chain fatty acid transporter op hp0690-hp0693 + (39)
        HP1181 JHP1107 0.47 Predicted multidrug efflux transporter op hp1181-hp1182 − (39)
    Unknown
        HP0747 JHP0684 0.21 Predicted S-adenosylmethionine-dependent methyltransferase op hp0745-hp0750?
    Hypothetical
        HP0697 JHP0631 0.07 Conserved hypothetical protein op hp0695-hp0697 + (39)
        HP0902 JHP0839 0.42 Conserved hypothetical protein op hp0902-hp0901
        HP0423 0.43 Hypothetical protein op hp0427-hp0423? + (7, 30)
        HP0699 JHP0639 0.48 Hypothetical protein op hp0698-hp0703
        HP0874 JHP0808 0.29 Hypothetical protein m? + (39)
        HP1412 JHP1307 0.40 Hypothetical protein op hp1408-hp1412? + (30, 39)
HP1021-repressed genesa
    Ammonia production
        HP0070 JHP0065 2.94 Urease accessory protein, ureE op hp0071-hp0067 + (30, 39)
        HP1238 JHP1559 2.80 Aliphatic amidase, amiF m + (7, 20, 30)
    Biosynthesis of cofactors, prosthetic groups, and carriers
        HP0306 JHP0291 2.24 Glutamate-1-semialdehyde 2,1-aminomutase, hemL op hp0305-hp0308 + (20, 30, 39)
    Cell envelope
        HP0229 JHP0214 2.49 Outer membrane protein, omp6 (hopA) m − (7, 20, 30, 39)
        HP0722 JHP0659 2.69 Outer membrane protein, omp16 (hopO) m − (7, 20, 30)
        HP0725 JHP0662 3.77 Outer membrane protein, omp17 (hopP) m − (7, 20, 30)
        HP1083 JHP0342 2.40 Predicted outer membrane protein, hofB m − (30)
    Energy metabolism
        HP0954 JHP0888 2.65 NAD(P)H-dependent nitroreductase op hp0966-hp0954? + (30)
        HP1399 JHP1427 2.52 Arginase, rocF m + (39), − (30)
    Fatty acid and phospholipid metabolism
        HP0950 JHP0844 2.87 Predicted acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, accD op hp0950-hp0948 + (39)
    Transport and binding proteins
        HP0686 JHP0626 2.32 Iron(III) dicitrate transport protein, fecA1 m − (30)
        HP1400 JHP1426 4.33 Iron(III) dicitrate transport protein, fecA3 m − (7)
        HP1174 JHP1101 3.42 Glucose/galactose transporter m − (30)
    Pathogenesis
        HP0967 2.13 Predicted virulence-associate protein D m
    Hypothetical
        HP1242 JHP1163 2.59 Conserved hypothetical protein m
        HP0966 JHP0900/JHP0901 2.42 Conserved hypothetical protein op hp0966-hp0954?
        HP1334 3.86 Conserved hypothetical protein m − (39)
        HP0937 JHP0872 2.22 Conserved hypothetical protein m? + (39)
        HP0938 JHP0873 3.14 Conserved hypothetical protein m?
        HP0948 JHP0882 2.07 Conserved hypothetical protein op hp0950-hp0948 + (39)
        HP0946 JHP0880 2.12 Conserved hypothetical integral membrane protein m
        HP0097 JHP0089 2.10 Hypothetical protein m − (20, 39)
        HP0242 JHP0227 2.97 Hypothetical protein op hp0243-hp0236? + (30, 39)
        HP0945 3.73 Hypothetical protein m
        HP0947 JHP0881 2.83 Hypothetical protein m − (30)
        HP0953 JHP0887 2.08 Hypothetical protein m? + (39)
        HP0990 JHP0938 2.12 Hypothetical protein m + (39)
        HP0992 2.41 Hypothetical protein m
a

Genes listed are those whose transcription, according to microarray analysis, differed more than twofold (ratio of >2.0 and <0.5) in the HP0121-deficient mutant H. pylori 26695/HP1021::km compared to the 26695 wild-type strain.

b

ORF numbers and prediction of transcriptional units are according to the genome sequences of H. pylori 26695 and J99 (2, 35).

c

The functional annotation is that used by the PyloriGene database (http://www.pasteur.fr/english.html).

d

m indicates monocistronically transcribed genes, and op indicates putative transcriptional units. A question mark indicates that the proposed operon structure cannot be unambiguously deduced from the genome sequence.

e

Where a reference(s) is given, pH-responsive transcription or ArsR∼P-dependent regulation was reported by Merrell et al. (20), Wen et al. (39), Bury-Moné et al. (7), or Pflock et al. (30). A plus sign denotes positive regulation by a low pH or ArsR∼P, and a minus sign denotes negative regulation by a low pH or ArsR∼P.