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. 1987 Apr;127(1):97–105.

Rejection of combined heart-lung transplants in rats. Function and pathology.

J Prop, H D Tazelaar, M E Billingham
PMCID: PMC1899608  PMID: 3105325

Abstract

Clinical experience with combined heart-lung transplantation has made it clear that several aspects of the rejection of combined organ transplants need further investigation. In this study, the rejection process of combined heart-lung allografts was examined for determining whether it affects the lung and heart synchronously and whether it differs from rejection when these organs are transplanted alone. The lungs of the combined allografts were functionally rejected prior to the heart (6 and 11 days, respectively). Accordingly, the pathologic changes were most severe in the lungs. The rejection pathology of these combinedly transplanted organs was similar to that described for lungs and hearts transplanted separately, except that the airways were found to be more extensively involved than had been appreciated in previous studies. It is concluded that after combined transplantation the lung is more prone to rejection than the heart. On the basis of the present observations, the definition of sequential rejection phases in the lung was slightly altered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Billingham M. E. Endomyocardial biopsy detection of acute rejection in cardiac allograft recipients. Heart Vessels Suppl. 1985;1:86–90. doi: 10.1007/BF02072369. [DOI] [PubMed] [Google Scholar]
  2. Burke C. M., Theodore J., Dawkins K. D., Yousem S. A., Blank N., Billingham M. E., Van Kessel A., Jamieson S. W., Oyer P. E., Baldwin J. C. Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart-lung transplantation. Chest. 1984 Dec;86(6):824–829. doi: 10.1378/chest.86.6.824. [DOI] [PubMed] [Google Scholar]
  3. Chiles C., Guthaner D. F., Jamieson S. W., Stinson E. B., Oyer P. E., Silverman J. F. Heart-lung transplantation: the postoperative chest radiograph. Radiology. 1985 Feb;154(2):299–304. doi: 10.1148/radiology.154.2.3917571. [DOI] [PubMed] [Google Scholar]
  4. Griepp R. B., Stinson E. B., Dong E., Jr, Clark D. A., Shumway N. E. Acute rejection of the allogrfted human heart. Ann Thorac Surg. 1971 Aug;12(2):113–126. doi: 10.1016/s0003-4975(10)65102-8. [DOI] [PubMed] [Google Scholar]
  5. Lower R. R., Dong E., Jr, Glazener F. S. Electrocardiograms of dogs with heart homografts. Circulation. 1966 Mar;33(3):455–460. doi: 10.1161/01.cir.33.3.455. [DOI] [PubMed] [Google Scholar]
  6. McGregor C. G., Baldwin J. C., Jamieson S. W., Billingham M. E., Yousem S. A., Burke C. M., Oyer P. E., Stinson E. B., Shumway N. E. Isolated pulmonary rejection after combined heart-lung transplantation. J Thorac Cardiovasc Surg. 1985 Oct;90(4):623–626. [PubMed] [Google Scholar]
  7. Prop J., Ehrie M. G., Crapo J. D., Nieuwenhuis P., Wildevuur C. R. Reimplantation response in isografted rat lungs. Analysis of causal factors. J Thorac Cardiovasc Surg. 1984 May;87(5):702–711. [PubMed] [Google Scholar]
  8. Prop J., Kuijpers K., Petersen A. H., Bartels H. L., Nieuwenhuis P., Wildevuur C. R. Why are lung allografts more vigorously rejected than hearts? J Heart Transplant. 1985 Jul-Aug;4(4):433–436. [PubMed] [Google Scholar]
  9. Prop J., Nieuwenhuis P., Wildevuur C. R. Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes. Transplantation. 1985 Jul;40(1):25–30. doi: 10.1097/00007890-198507000-00006. [DOI] [PubMed] [Google Scholar]
  10. Prop J., Wildevuur C. R., Nieuwenhuis P. Lung allograft rejection in the rat. II. Specific immunological properties of lung grafts. Transplantation. 1985 Aug;40(2):126–131. doi: 10.1097/00007890-198508000-00003. [DOI] [PubMed] [Google Scholar]
  11. Prop J., Wildevuur C. R., Nieuwenhuis P. Lung allograft rejection in the rat. III. Corresponding morphological rejection phases in various rat strain combinations. Transplantation. 1985 Aug;40(2):132–136. doi: 10.1097/00007890-198508000-00004. [DOI] [PubMed] [Google Scholar]
  12. Reitz B. A., Gaudiani V. A., Hunt S. A., Wallwork J., Billingham M. E., Oyer P. E., Baumgartner W. A., Jamieson S. W., Stinson E. B., Shumway N. E. Diagnosis and treatment of allograft rejection in heart-lung transplant recipients. J Thorac Cardiovasc Surg. 1983 Mar;85(3):354–361. [PubMed] [Google Scholar]
  13. Reitz B. A., Wallwork J. L., Hunt S. A., Pennock J. L., Billingham M. E., Oyer P. E., Stinson E. B., Shumway N. E. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med. 1982 Mar 11;306(10):557–564. doi: 10.1056/NEJM198203113061001. [DOI] [PubMed] [Google Scholar]
  14. Yousem S. A., Burke C. M., Billingham M. E. Pathologic pulmonary alterations in long-term human heart-lung transplantation. Hum Pathol. 1985 Sep;16(9):911–923. doi: 10.1016/s0046-8177(85)80130-1. [DOI] [PubMed] [Google Scholar]
  15. Zeevi A., Fung J. J., Paradis I. L., Dauber J. H., Griffith B. P., Hardesty R. L., Duquesnoy R. J. Lymphocytes of bronchoalveolar lavages from heart-lung transplant recipients. J Heart Transplant. 1985 Jul-Aug;4(4):417–421. [PubMed] [Google Scholar]

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