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. 1987 Aug;128(2):210–215.

A pancreatic venular defect in the BB/Wor rat.

G Majno, I Joris, E S Handler, J Desemone, J P Mordes, A A Rossini
PMCID: PMC1899615  PMID: 3618725

Abstract

BB rats develop spontaneous autoimmune diabetes mellitus characterized morphologically by insulitis, an inflammatory lymphocytic infiltration of the islets of Langerhans. To investigate the role of the vascular endothelium of the pancreas in this destructive process, the authors injected diabetes-prone (DP) and diabetes-resistant (DR) BB/Wor rats as well as other nondiabetic strains of rats with Monastral blue B, a colloidal pigment that identifies leaky microvasculature. They found evidence of a venular defect limited to the pancreas that is specific to the BB rat. Light- and electron-microscopic evidence suggests that this defect is due to a population of trapped (marginating) intravascular monocytes, which may be activated by the colloidal pigment and release vasoactive mediators.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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