Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1984 Apr;115(1):25–30.

Experimental pyelonephritis. The effect of T-cell deficiency on the course of hematogenous enterococcal pyelonephritis in the mouse.

H Pitchon, R Glassock, G M Kalmanson, L B Guze
PMCID: PMC1900355  PMID: 6424480

Abstract

The course of experimental hematogenous pyelonephritis due to Streptococcus faecalis was compared in athymic (nu/nu) mice and euthymic (nu/+) littermates. Up to 7 weeks following infection, there were no significant differences in renal microbial populations. At 63 and 107-131 days there was significant escalation of infection in nu/nu mice, while the nu/+ mice were decreasing their infections. There was no increase in gross abscess formation in nu/nu mice, but in late stages significantly more gross scarring occurred in nu/nu as compared with nu/+ mice. Microscopically there was also greater scarring in nu/nu mice late in the disease, except for calyceal lesions. The data suggest that immunologic factors (T cells) are involved in the pathogenesis of chronic pyelonephritis.

Full text

PDF
25

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bakker-Woudenberg I. A., de Bos P., van Leeuwen W. B., Michel M. F. Efficacy of ampicillin therapy in experimental listeriosis in mice with impaired T-cell-mediated immune response. Antimicrob Agents Chemother. 1981 Jan;19(1):76–81. doi: 10.1128/aac.19.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaman B. L., Gershwin M. E., Maslan S. Infectious agents in immunodeficient murine models: pathogenicity of Actinomyces israelii serotype I in congenitally athymic (nude) mice. Infect Immun. 1979 May;24(2):583–585. doi: 10.1128/iai.24.2.583-585.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beaman B. L., Gershwin M. E., Maslan S. Infectious agents in immunodeficient murine models: pathogenicity of Nocardia asteroides in congenitally athymic (nude) and hereditarily asplenic (Dh/+) mice. Infect Immun. 1978 May;20(2):381–387. doi: 10.1128/iai.20.2.381-387.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beaman B. L., Goldstein E., Gershwin M. E., Maslan S., Lippert W. Lung response to congenitally athymic (nude), heterozygous, and Swiss Webster mice to aerogenic and intranasal infection by Nocardia asteroides. Infect Immun. 1978 Dec;22(3):867–877. doi: 10.1128/iai.22.3.867-877.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beaman L., Pappagianis D., Benjamini E. Significance of T cells in resistance to experimental murine coccidioidomycosis. Infect Immun. 1977 Sep;17(3):580–585. doi: 10.1128/iai.17.3.580-585.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cheers C., Waller R. Activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice. J Immunol. 1975 Sep;115(3):844–847. [PubMed] [Google Scholar]
  7. Coles G. A., Chick S., Hopkins M., Ling R., Radford N. J. The role of the T cell in experimental pyelonephritis. Clin Exp Immunol. 1974 Apr;16(4):629–636. [PMC free article] [PubMed] [Google Scholar]
  8. Collins F. M., Congdon C. C., Morrison N. E. Growth of mycobacterium bovis (BCG) in T lymphocyte-depleted mice. Infect Immun. 1975 Jan;11(1):57–64. doi: 10.1128/iai.11.1.57-64.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Emmerling P., Finger H., Bockemühl J. Listeria monocytogenes infection in nude mice. Infect Immun. 1975 Aug;12(2):437–439. doi: 10.1128/iai.12.2.437-439.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Emmerling P., Finger H., Hof H. Cell-mediated resistance to infection with Listeria monocytogenes in nude mice. Infect Immun. 1977 Feb;15(2):382–385. doi: 10.1128/iai.15.2.382-385.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Folb P. I., Timme A., Horowitz A. Nocardia infections in congenitally athymic (nude) mice and in other inbred mouse strains. Infect Immun. 1977 Nov;18(2):459–466. doi: 10.1128/iai.18.2.459-466.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GUZE L. B., GOLDNER B. H., KALMANSON G. M. Pyelonephritis. I. Observations on the course of chronic non-obstructed enterococcal infection in the kidnev of the rat. Yale J Biol Med. 1961 Apr;33:372–385. [PMC free article] [PubMed] [Google Scholar]
  13. Glassock R. J., Kalmanson G. M., Guze L. B. Pyelonephritis. 18. Effect of treatment on the pathology of enterococcal pyelonephritis in the rat. Am J Pathol. 1974 Jul;76(1):49–62. [PMC free article] [PubMed] [Google Scholar]
  14. Glauser M. P., Lyons J. M., Braude A. I. Prevention of chronic experimental pyelonephritis by suppression of acute suppuration. J Clin Invest. 1978 Feb;61(2):403–407. doi: 10.1172/JCI108951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Graybill J. R., Drutz D. J. Host defense in cryptococcosis. II. Cryptococcosis in the nude mouse. Cell Immunol. 1978 Oct;40(2):263–274. doi: 10.1016/0008-8749(78)90334-9. [DOI] [PubMed] [Google Scholar]
  16. Hazlett L. D., Berk R. S. Heightened resistance of athymic, nude (nu/nu) mice to experimental Pseudomonas aeruginosa ocular infection. Infect Immun. 1978 Dec;22(3):926–933. doi: 10.1128/iai.22.3.926-933.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. KALMANSON G. M., HUBERT E. G., GUZE L. B. PYELONEPHRITIS. IV. ROLE OF SERUM BACTERICIDAL ACTIVITY AND ANTIBODY IN CHRONIC ENTEROCOCCAL PYELONEPHRITIS IN THE RAT. Proc Soc Exp Biol Med. 1963 Aug-Sep;113:918–921. doi: 10.3181/00379727-113-28531. [DOI] [PubMed] [Google Scholar]
  18. KALMANSON G. M., HUBERT E. G., GUZE L. B. PYELONEPHRITIS. IV. ROLE OF SERUM BACTERICIDAL ACTIVITY AND ANTIBODY IN CHRONIC ENTEROCOCCAL PYELONEPHRITIS IN THE RAT. Proc Soc Exp Biol Med. 1963 Aug-Sep;113:918–921. doi: 10.3181/00379727-113-28531. [DOI] [PubMed] [Google Scholar]
  19. Keystone E. C., Taylor-Robinson D., Osborn M. F., Ling L., Pope C., Fornasier V. Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis. Infect Immun. 1980 Jan;27(1):192–196. doi: 10.1128/iai.27.1.192-196.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Miller T. E., Simpson G., Ormrod D. J. Quantitation of immunoglobulin-bearing lymphocytes and the lymphocyte response to PHA in experimental pyelonephritis. Clin Exp Immunol. 1975 Sep;21(3):474–484. doi: 10.1002/aic.690210307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Mogensen S. C., Andersen H. K. Role of activated macrophages in resistance of congenitally athymic nude mice to hepatitis induced by herpes simplex virus type 2. Infect Immun. 1978 Mar;19(3):792–798. doi: 10.1128/iai.19.3.792-798.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nickol A. D., Bonventre P. F. Anomalous high native resistance to athymic mice to bacterial pathogens. Infect Immun. 1977 Dec;18(3):636–645. doi: 10.1128/iai.18.3.636-645.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rao G. R., Rawls W. E., Perey D. Y., Tompkins W. A. Macrophage activation in congenitally athymic mice raised under conventional or germ-free conditions. J Reticuloendothel Soc. 1977 Jan;21(1):13–20. [PubMed] [Google Scholar]
  24. Rogers T. J., Balish E., Manning D. D. The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis. J Reticuloendothel Soc. 1976 Oct;20(4):291–298. [PubMed] [Google Scholar]
  25. Sher N. A., Chaparas S. D., Greenberg L. E., Merchant E. B., Vickers J. H. Response of congenitally athymic (nude) mice to infection with Mycobacterium bovis (strain BCG). J Natl Cancer Inst. 1975 Jun;54(6):1419–1426. doi: 10.1093/jnci/54.6.1419. [DOI] [PubMed] [Google Scholar]
  26. Shiraishi A., Nakagaki K., Arai T. Experimental sporotrichosis in congenitally athymic (nude) mice. J Reticuloendothel Soc. 1979 Sep;26(3):333–336. [PubMed] [Google Scholar]
  27. Smith J. W., Adkins M. J., McCreary D. Local immune response in experimental pyelonephritis in the rabbit. I. Morphological and functional features of the lymphocytic infiltrate. Immunology. 1975 Dec;29(6):1067–1076. [PMC free article] [PubMed] [Google Scholar]
  28. Tanaka H. Mycoplasma pulmonis arthritis in congenitally athymic (nude) mice. Clinical and biological features. Microbiol Immunol. 1979;23(11):1055–1065. doi: 10.1111/j.1348-0421.1979.tb00537.x. [DOI] [PubMed] [Google Scholar]
  29. Ueda K., Yamazaki S., Someya S. Experimental mycobacterial infection in congenitally athymic "nude" mice. J Reticuloendothel Soc. 1976 Feb;19(2):77–90. [PubMed] [Google Scholar]
  30. Williams D. M., Graybill J. R., Drutz D. J. Histoplasma capsulatum infection in nude mice. Infect Immun. 1978 Sep;21(3):973–977. doi: 10.1128/iai.21.3.973-977.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES