Abstract
Both the tissue lactate dehydrogenase (LDH) isoenzyme pattern and total LDH activity were investigated in a series of human uterine sarcomas and cell lines derived from these tumors. Abnormal LDH isoenzyme patterns characterized by shifts toward the muscle isoenzyme forms (LDH4 and 5) were found in some, but not all, of the sarcomas. The tumors containing rhabdomyosarcomatous elements usually had normal or only slightly altered LDH isoenzyme patterns. The LDH isoenzyme patterns expressed by cultured cell lines established from the uterine sarcomas, in general, resembled those found in the primary tumors. These results suggest that the normal or near normal LDH isoenzyme distributions found in uterine sarcomas with rhabdomyosarcomatous differentiation may be a potential characteristic which may be used for distinguishing these tumors from other uterine sarcomas.
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- GOLDMAN R. D., KAPLAN N. O. ALTERATIONS OF TISSUE LACTATE DEHYDROGENASE IN HUMAN NEOPLASMS. Biochim Biophys Acta. 1963 Nov 8;77:515–518. doi: 10.1016/0006-3002(63)90533-x. [DOI] [PubMed] [Google Scholar]
- GOLDMAN R. D., KAPLAN N. O., HALL T. C. LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES. Cancer Res. 1964 Apr;24:389–399. [PubMed] [Google Scholar]
- Mourant A. E., Beckman L., Beckman G., Nilsson L. O., Tills D. Erythrocyte lactate dehydrogenase variants in the Icelandic and Swedish populations. Acta Genet Stat Med. 1968;18(6):553–555. doi: 10.1159/000152179. [DOI] [PubMed] [Google Scholar]
- Okabe K., Hayakawa T., Hamada M., Koike M. Purification and comparative properties of human lactate dehydrogenase isozymes from uterus, uterine myoma, and cervical cancer. Biochemistry. 1968 Jan;7(1):79–90. doi: 10.1021/bi00841a011. [DOI] [PubMed] [Google Scholar]
- Schapira F. Isozymes and cancer. Adv Cancer Res. 1973;18:77–153. doi: 10.1016/s0065-230x(08)60751-4. [DOI] [PubMed] [Google Scholar]
- Siegal G. P., Taylor L. L., 3rd, Nelson K. G., Reddick R. L., Frazelle M., Siegfried J. M., Walton L. A., Kaufman D. G. Characterization of a pure heterologous sarcoma of the uterus: rhabdomyosarcoma of the corpus. Int J Gynecol Pathol. 1983;2(3):303–315. doi: 10.1097/00004347-198303000-00008. [DOI] [PubMed] [Google Scholar]
- Spellman C. M., Fottrell P. F., Baynes S., O'Dwyer E. M., Clinch J. D. A study of some enzymes and isoenzymes of carbohydrate metabolism in human endometrium during the menstrual cycle. Clin Chim Acta. 1973 Oct 30;48(3):259–268. doi: 10.1016/0009-8981(73)90194-0. [DOI] [PubMed] [Google Scholar]
- Stagg B. H., Whyley G. A. Some characteristics of lactate dehydrogenase isoenzymes in tumours of the female genital tract. Clin Chim Acta. 1968 Dec;22(4):521–533. doi: 10.1016/0009-8981(68)90100-9. [DOI] [PubMed] [Google Scholar]
- Starkweather W. H., Spencer H. H., Schwarz E. L., Schoch H. K. The electrophoretic separation of lactate dehydrogenase isoenzymes and their evaluation in clinical medicine. J Lab Clin Med. 1966 Feb;67(2):329–343. [PubMed] [Google Scholar]
- WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]