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. 1984 Jul;116(1):107–114.

Differences in the occurrence of hypertension among (NZB X NZW)F1, MRL-lpr, and BXSB mice with lupus nephritis.

U H Rudofsky, R L Dilwith, J B Roths, D A Lawrence, V E Kelley, A M Magro
PMCID: PMC1900373  PMID: 6377906

Abstract

Lupus-prone (NZB X NZW)F1 (B X W) mice and MRL-lpr and BXSB mice were examined for the prevalence of hypertension and levels of plasma renin activity (PRA). Hypertension (greater than 145 mmHg) was observed only in female and male B X W mice with severe nephritis; in female MRL-lpr and male BXSB mice severe nephritis developed without blood pressure elevation (80-135 mmHg). The B X W parental strains, NZB and NZW, and the MRL-lpr congenic partners, MRL- +, did not become hypertensive as they aged. Other strains of mice, aged 3-32 months (A/HeN, BALB/cJ, BALB/cByJ, B10.S/Sg, B10.D2/ oSn , CBA/J, C3H/HeJ, SJL/J and [SJL X NZW]F1), also had normal blood pressure (98-122 mmHg). All mice with lupus nephritis had low PRA, even those with hypertension; furthermore, the MRL-lpr strain had low or undetectable PRA (2 +/- 1 ng/ml/hr), even when kidneys were normal. NZB, NZW, and MRL- + mice had normal PRA (10-16 ng/ml/hr). Thus, B X W mice frequently developed low renin hypertension during the last phase of their renal disease; whereas MRL-lpr and BXSB mice died from renal disease without observable increases in blood pressure.

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Selected References

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  1. Andrews B. S., Eisenberg R. A., Theofilopoulos A. N., Izui S., Wilson C. B., McConahey P. J., Murphy E. D., Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198–1215. doi: 10.1084/jem.148.5.1198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennett W. M., Walker R. G., Henry J. P., Kincaid-Smith P. Chronic interstitial nephropathy in mice induced by psychosocial stress: potentiation by caffeine. Nephron. 1983;34(2):110–113. doi: 10.1159/000182992. [DOI] [PubMed] [Google Scholar]
  3. Berden J. H., Hang L., McConahey P. J., Dixon F. J. Analysis of vascular lesions in murine SLE. I. Association with serologic abnormalities. J Immunol. 1983 Apr;130(4):1699–1705. [PubMed] [Google Scholar]
  4. Beyer M. M., Steinberg A. D., Nicastri A. D., Friedman E. A. Unilateral nephrectomy: effect on survival in NZB/NZW mice. Science. 1977 Nov 4;198(4316):511–513. doi: 10.1126/science.143718. [DOI] [PubMed] [Google Scholar]
  5. Dixon F. J. Murine SLE models and autoimmune disease. Hosp Pract (Hosp Ed) 1982 Mar;17(3):63–73. doi: 10.1080/21548331.1982.11702287. [DOI] [PubMed] [Google Scholar]
  6. Fernandes G., Yunis E. J., Good R. A. Influence of diet on survival of mice. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1279–1283. doi: 10.1073/pnas.73.4.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frohlich E. D. Hemodynamic factors in the pathogenesis and maintenance of hypertension. Fed Proc. 1982 Jun;41(8):2400–2408. [PubMed] [Google Scholar]
  8. Gabrielsen A. E., Olsen C. T. Prolonged survival of hypertransfused NZB/NZW mice. Immunology. 1977 Oct;33(4):449–452. [PMC free article] [PubMed] [Google Scholar]
  9. Gilliam J. N., Hurd E. R., Ziff M. Subepidermal deposition of immunoglobulin in NZB/NZW F hybrid mice. J Immunol. 1975 Jan;114(1 Pt 1):133–137. [PubMed] [Google Scholar]
  10. Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
  11. Hurd E. R., Johnston J. M., Okita J. R., MacDonald P. C., Ziff M., Gilliam J. W. Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet. J Clin Invest. 1981 Feb;67(2):476–485. doi: 10.1172/JCI110056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kelley V. E., Winkelstein A. Age- and sex-related glomerulonephritis in New Zealand white mice. Clin Immunol Immunopathol. 1980 Jun;16(2):142–150. doi: 10.1016/0090-1229(80)90198-1. [DOI] [PubMed] [Google Scholar]
  13. Kelley V. E., Winkelstein A., Izui S., Dixon F. J. Prostaglandin E1 inhibits T-cell proliferation and renal disease in MRL/1 mice. Clin Immunol Immunopathol. 1981 Nov;21(2):190–203. doi: 10.1016/0090-1229(81)90208-7. [DOI] [PubMed] [Google Scholar]
  14. Kelley V. E., Winkelstein A., Izui S. Effect of prostaglandin E on immune complex nephritis in NZB/W mice. Lab Invest. 1979 Dec;41(6):531–537. [PubMed] [Google Scholar]
  15. Magro A. M., Rudofsky U. H. Plasma renin activity decrease precedes spontaneous focal glomerular sclerosis in aging rats. Nephron. 1982;31(3):245–253. doi: 10.1159/000182654. [DOI] [PubMed] [Google Scholar]
  16. Nasjletti A., Malik K. U. Interrelations between prostaglandins and vasoconstrictor hormones: contribution to blood pressure regulation. Fed Proc. 1982 Jun;41(8):2394–2399. [PubMed] [Google Scholar]
  17. Prickett J. D., Robinson D. R., Steinberg A. D. Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice. J Clin Invest. 1981 Aug;68(2):556–559. doi: 10.1172/JCI110288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rudofsky U. H., Dilwith R. L., Tung K. S. Susceptibility differences of inbred mice to induction of autoimmune renal tubulointerstitial lesions. Lab Invest. 1980 Nov;43(5):463–470. [PubMed] [Google Scholar]
  20. Rudofsky U. H. Spontaneous and induced autoantibodies to renal and nonrenal basement membranes in mice. Clin Immunol Immunopathol. 1980 Feb;15(2):200–212. doi: 10.1016/0090-1229(80)90031-8. [DOI] [PubMed] [Google Scholar]
  21. Rudofsky U. H., Urizar R. E., Gabrielsen A. E., Simmons A. D., Olsen C. T. Dactinomycin treatment of murine lupus erythematosus. I. Renal disease and longevity. Lab Invest. 1978 Nov;39(5):441–448. [PubMed] [Google Scholar]
  22. Simpson L. O. A mouse model of spontaneous renal hypertension. blood pressure, heart weight, kidney weight and proteinuria relationships in NZB x OUW F1 hybrid female mice. Pathology. 1980 Jul;12(3):347–357. doi: 10.3109/00313028009077096. [DOI] [PubMed] [Google Scholar]
  23. Sommer V. M., Rudofsky U. H., Gabrielsen A. E. Immune complexes in skin of NZB/NZW mice. Clin Exp Immunol. 1975 Dec;22(3):461–467. [PMC free article] [PubMed] [Google Scholar]
  24. Svendsen U. G., Koch C. M., Rubin B. Genetic control of the spontaneous hypertension in the NZB/Cr strain of mice. Immunogenetic considerations. Acta Pathol Microbiol Scand C. 1979 Aug;87C(4):269–273. [PubMed] [Google Scholar]
  25. Theofilopoulos A. N., Dixon F. J. Autoimmune diseases: immunopathology and etiopathogenesis. Am J Pathol. 1982 Sep;108(3):319–365. [PMC free article] [PubMed] [Google Scholar]
  26. Vander A. J., Henry J. P., Stephens P. M., Kay L. L., Mouw D. R. Plasma renin activity in psychosocial hypertension of CBA mice. Circ Res. 1978 Apr;42(4):496–502. doi: 10.1161/01.res.42.4.496. [DOI] [PubMed] [Google Scholar]

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