Abstract
Seventy-three human tumors and adjacent nonneoplastic tissues were analyzed immunohistochemically for the presence of growth-hormone-releasing factor (GRF). Four of 9 pancreatic endocrine tumors, 2 of 3 appendiceal carcinoids, and 1 of 5 cecal carcinoids were immunoreactive for GRF. One of the GRF-containing pancreatic tumors was associated with acromegaly. Histologically, the growth patterns of these tumors were variable, and the distribution of immunoreactive cells was patchy and irregular. There were no normal cells that contained GRF. These results indicate that GRF production by human tumors is more common than previously thought, although clinical acromegaly may not be apparent in patients who harbor such neoplasms.
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- Bloch B., Brazeau P., Ling N., Bohlen P., Esch F., Wehrenberg W. B., Benoit R., Bloom F., Guillemin R. Immunohistochemical detection of growth hormone-releasing factor in brain. Nature. 1983 Feb 17;301(5901):607–608. doi: 10.1038/301607a0. [DOI] [PubMed] [Google Scholar]
- Böhlen P., Brazeau P., Bloch B., Ling N., Gaillard R., Guillemin R. Human hypothalamic growth hormone releasing factor (GRF): evidence for two forms identical to tumor derived GRF-44-NH2 and GRF-40. Biochem Biophys Res Commun. 1983 Aug 12;114(3):930–936. doi: 10.1016/0006-291x(83)90649-6. [DOI] [PubMed] [Google Scholar]
- Gubler U., Monahan J. J., Lomedico P. T., Bhatt R. S., Collier K. J., Hoffman B. J., Böhlen P., Esch F., Ling N., Zeytin F. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4311–4314. doi: 10.1073/pnas.80.14.4311. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guillemin R., Brazeau P., Böhlen P., Esch F., Ling N., Wehrenberg W. B. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982 Nov 5;218(4572):585–587. doi: 10.1126/science.6812220. [DOI] [PubMed] [Google Scholar]
- Leveston S. A., McKeel D. W., Jr, Buckley P. J., Deschryver K., Greider M. H., Jaffe B. M., Daughaday W. H. Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. J Clin Endocrinol Metab. 1981 Oct;53(4):682–689. doi: 10.1210/jcem-53-4-682. [DOI] [PubMed] [Google Scholar]
- Rivier J., Spiess J., Thorner M., Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature. 1982 Nov 18;300(5889):276–278. doi: 10.1038/300276a0. [DOI] [PubMed] [Google Scholar]
- Scheithauer B. W., Carpenter P. C., Bloch B., Brazeau P. Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor. Am J Med. 1984 Apr;76(4):605–616. doi: 10.1016/0002-9343(84)90284-5. [DOI] [PubMed] [Google Scholar]
- Shibasaki T., Kiyosawa Y., Masuda A., Nakahara M., Imaki T., Wakabayashi I., Demura H., Shizume K., Ling N. Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts. J Clin Endocrinol Metab. 1984 Aug;59(2):263–268. doi: 10.1210/jcem-59-2-263. [DOI] [PubMed] [Google Scholar]
- Yamaguchi K., Abe K., Suzuki M., Adachi I., Kimura S., Shimada A., Ohno H., Kanai A., Kameya T. Production of immunoreactive pancreatic growth hormone-releasing factor in small cell carcinoma of the lung. Gan. 1983 Dec;74(6):814–817. [PubMed] [Google Scholar]
- Yang K., Ulich T., Cheng L., Lewin K. J. The neuroendocrine products of intestinal carcinoids. An immunoperoxidase study of 35 carcinoid tumors stained for serotonin and eight polypeptide hormones. Cancer. 1983 May 15;51(10):1918–1926. doi: 10.1002/1097-0142(19830515)51:10<1918::aid-cncr2820511027>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]