Abstract
Production and delivery of macrophages to the alveoli are dependent upon chemotactic and mitogenic stimuli. To determine whether these mechanisms occur uniformly throughout the lungs or are localized to the areas of particulate deposition, the authors instilled 4 mg of carbon in one lung of a rat, the other lung serving as a control. Following split-lung lavage, little change was seen in the number of cells lavaged from nontreated lungs, whereas the yield of macrophages from the black lungs rose from 32 X 10(4) to 400 X 10(4) after 2 days; control values were not attained until 3 weeks. Labeling indices for cell nuclei in the white lungs were slightly elevated, whereas in the black lungs the value rose from 0.4 to 1.0-1.5% for 3 weeks before falling to normal. The increased labeling was limited to interstitial cells. The results provide further support for the dual origin of alveolar macrophages and indicate the importance of local generation of chemotactic and mitogenic factors in stimulating the cellular response and in directing these cells to the sites of maximal deposition of particles.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adamson I. Y., Bowden D. H. Chemotactic and mitogenic components of the alveolar macrophage response to particles ad neutrophil chemoattractant. Am J Pathol. 1982 Oct;109(1):71–77. [PMC free article] [PubMed] [Google Scholar]
- Adamson I. Y., Bowden D. H. Dose response of the pulmonary macrophagic system to various particulates and its relationship to transepithelial passage of free particles. Exp Lung Res. 1981 Aug;2(3):165–175. doi: 10.3109/01902148109052312. [DOI] [PubMed] [Google Scholar]
- Adamson I. Y., Bowden D. H. Role of monocytes and interstitial cells in the generation of alveolar macrophages II. Kinetic studies after carbon loading. Lab Invest. 1980 May;42(5):518–524. [PubMed] [Google Scholar]
- Bowden D. H., Adamson I. Y. Alveolar macrophage response to carbon in monocyte-depleted mice. Am Rev Respir Dis. 1982 Oct;126(4):708–711. doi: 10.1164/arrd.1982.126.4.708. [DOI] [PubMed] [Google Scholar]
- Bowden D. H., Adamson I. Y. Role of monocytes and interstitial cells in the generation of alveolar macrophages I. Kinetic studies of normal mice. Lab Invest. 1980 May;42(5):511–517. [PubMed] [Google Scholar]
- Dauber J. H., Daniele R. P. Secretion of chemotaxins by guinea pig lung macrophages. I. The spectrum of inflammatory cell responses. Exp Lung Res. 1980 Mar;1(1):23–32. doi: 10.3109/01902148009057510. [DOI] [PubMed] [Google Scholar]
- Golde D. W., Finley T. N., Cline M. J. The pulmonary macrophage in acute leukemia. N Engl J Med. 1974 Apr 18;290(16):875–878. doi: 10.1056/NEJM197404182901603. [DOI] [PubMed] [Google Scholar]
- Gross N. J. Alveolar macrophage number: an index of the effect of radiation on the lungs. Radiat Res. 1977 Nov;72(2):325–332. [PubMed] [Google Scholar]
- Meyer O. T., Dannenberg A. M., Jr Radiation, infection, and macrophage function. II. Effect of whole body radiation on the number of pulmonary alveolar macrophages and their levels of hydrolytic enzymes. J Reticuloendothel Soc. 1970 Jan;7(1):79–90. [PubMed] [Google Scholar]
- Privalova L. I., Katsnelson B. A., Osipenko A. B., Yushkov B. N., Babushkina L. G. Response of a phagocyte cell system to products of macrophage breakdown as a probable mechanism of alveolar phagocytosis adaptation to deposition of particles of different cytotoxicity. Environ Health Perspect. 1980 Apr;35:205–218. doi: 10.1289/ehp.8035205. [DOI] [PMC free article] [PubMed] [Google Scholar]