Abstract
We encountered a case of native valve endocarditis due to Corynebacterium CDC group I1 which was successfully controlled with antimicrobial agents alone. This organism and three other isolates of this group were susceptible to penicillin, vancomycin, and gentamicin. The combination of penicillin with subinhibitory concentrations of gentamicin resulted in a 1,000-fold decrease in CFU per milliliter at 24 h compared with penicillin alone. Augmentation of killing was noted also with vancomycin plus gentamicin but to a degree that did not meet strict criteria for bactericidal synergism.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Austin G. E., Hill E. O. Endocarditis due to Corynebacterium CDC group G2. J Infect Dis. 1983 Jun;147(6):1106–1106. doi: 10.1093/infdis/147.6.1106. [DOI] [PubMed] [Google Scholar]
- Eliakim R., Silkoff P., Lugassy G., Michel J. Corynebacterium xerosis endocarditis. Arch Intern Med. 1983 Oct;143(10):1995–1995. [PubMed] [Google Scholar]
- Farrer W. Four-valve endocarditis caused by corynebacterium CDC group I1. South Med J. 1987 Jul;80(7):923–925. doi: 10.1097/00007611-198707000-00031. [DOI] [PubMed] [Google Scholar]
- Geraci J. E., Forth R. J., Ellis F. H., Jr Postoperative prosthetic valve bacterial endocarditis due to Corynebacterium xerosis. Mayo Clin Proc. 1967 Nov;42(11):736–743. [PubMed] [Google Scholar]
- Gerry J. L., Greenough W. B., 3rd Diphtheroid endocarditis. Report of nine cases and review of the literature. Johns Hopkins Med J. 1976 Aug;139(2):61–68. [PubMed] [Google Scholar]
- Johnson W. D., Cobbs C. G., Arditi L. I., Kaye D. Diphtheroid endocarditis after insertion of a prosthetic heart valve. Report of two cases. JAMA. 1968 Mar 11;203(11):919–921. [PubMed] [Google Scholar]
- Jootar P., Gherunpong V., Saitanu K. Corynebacterium pyogenes endocarditis. Report of a case with necropsy and review of the literature. J Med Assoc Thai. 1978 Oct;61(10):596–601. [PubMed] [Google Scholar]
- Lipsky B. A., Goldberger A. C., Tompkins L. S., Plorde J. J. Infections caused by nondiphtheria corynebacteria. Rev Infect Dis. 1982 Nov-Dec;4(6):1220–1235. doi: 10.1093/clinids/4.6.1220. [DOI] [PubMed] [Google Scholar]
- Love J. W., Medina D., Anderson S., Braniff B. Infective endocarditis due to Corynebacterium diphtheriae: report of a case and review of the literature. Johns Hopkins Med J. 1981 Jan;148(1):41–42. [PubMed] [Google Scholar]
- Murray B. E., Karchmer A. W., Moellering R. C., Jr Diphtheroid prosthetic valve endocarditis. A study of clinical features and infecting organisms. Am J Med. 1980 Dec;69(6):838–848. doi: 10.1016/s0002-9343(80)80009-x. [DOI] [PubMed] [Google Scholar]
- Pearson R. D., Steigbigel R. T., Davis H. T., Chapman S. W. Method of reliable determination of minimal lethal antibiotic concentrations. Antimicrob Agents Chemother. 1980 Nov;18(5):699–708. doi: 10.1128/aac.18.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vale J. A., Scott G. W. Corynebacterium bovis as a cause of human disease. Lancet. 1977 Oct 1;2(8040):682–684. doi: 10.1016/s0140-6736(77)90495-0. [DOI] [PubMed] [Google Scholar]
- Wilson W. R., Danielson G. K., Giuliani E. R., Geraci J. E. Prosthetic valve endocarditis. Mayo Clin Proc. 1982 Mar;57(3):155–161. [PubMed] [Google Scholar]
