Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1980 Aug;100(2):403–410.

Consistent fluctuations in quantities of circulating immune complexes during progressive and regressive phases of tumor growth.

J C Jennette
PMCID: PMC1903543  PMID: 7406017

Abstract

Circulating immune complexes (CIC) were quantitated by a Raji cell radioimmunoassay in sera from Brown Norway rats bearing progressing or regressing methylcholanthrene-induced sarcomas. Quantitative profiles of CIC over time were related to tumor dose, tumor mass, and the regressive or progressive course of tumor growth. Animals bearing progressing tumors demonstrated an initial peak of CIC levels by 7 weeks but thereafter displayed a persistent decline in quantities of CIC despite continued tumor growth. Animals bearing regressing tumors were found to have a more directly proportional relationship between the tumor mass and the levels of CIC, but the appearance and disappearance of CIC lagged slightly behind the appearance and disappearance of the tumor. These data are almost identical to data previously published detailing quantities of CIC in BN and Lewis rats bearing Moloney sarcomas and are similar to fluctuations in CIC observed in animals and humans hosting a number of disparate neoplasms.

Full text

PDF
403

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Bowen J. G., Price M. R. Detection of circulating hepatoma D23 antigen and immune complexes in tumour bearer serum. Br J Cancer. 1973 Jul;28(1):16–24. doi: 10.1038/bjc.1973.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carpentier N. A., Lange G. T., Fiere D. M., Fournie G. J., Lambert P. H., Miescher P. A. Clinical relevance of circulating immune complexes in human leukemia. Association in acute leukemia of the presence of immune complexes with unfavorable prognosis. J Clin Invest. 1977 Oct;60(4):874–884. doi: 10.1172/JCI108842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heimer R., Klein G. Circulating immune complexes in sera of patients with Burkett's lymphoma and nasopharyngeal carcinoma. Int J Cancer. 1976 Sep 15;18(3):310–316. doi: 10.1002/ijc.2910180307. [DOI] [PubMed] [Google Scholar]
  4. Hoffken K., Meredith I. D., Robins R. A., Baldwin R. W., Davies C. J., Blamey R. W. Circulating immune complexes in patients with breast cancer. Br Med J. 1977 Jul 23;2(6081):218–220. doi: 10.1136/bmj.2.6081.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Höffken K., Price M. R., McLaughlin P. J., Moore V. E., Baldwin R. W. Circulating immune complexes in rats bearing chemically induced tumors. I. Sequential determination during the growth of tumours at various body sites. Int J Cancer. 1978 Apr 15;21(4):496–504. doi: 10.1002/ijc.2910210416. [DOI] [PubMed] [Google Scholar]
  6. Jennette J. C., Feldman J. D. Sequential quantitation of circulating immune complexes in syngeneic and allogeneic rats bearing Moloney sarcomas. J Immunol. 1977 Jun;118(6):2269–2274. [PubMed] [Google Scholar]
  7. Jose D. G., Seshadri R. Circulating immune complexes in human neuroblastoma: direct assay and role in blocking specific cellular immunity. Int J Cancer. 1974 Jun 15;13(6):824–838. doi: 10.1002/ijc.2910130610. [DOI] [PubMed] [Google Scholar]
  8. Long J. C., Hall C. L., Brown C. A., Stamatos C., Weitzman S. A., Carey K. Binding of soluble immune complexes in serum of patients with Hodgkin's disease to tissue cultures derived from the tumor. N Engl J Med. 1977 Aug 11;297(6):295–299. doi: 10.1056/NEJM197708112970602. [DOI] [PubMed] [Google Scholar]
  9. Mukojima T., Gunvén P., Klein G. Brief communication: circulating antigen-antibody complex associated with Epstein-Barr virus in recurrent Burkitt's lymphoma. J Natl Cancer Inst. 1973 Oct;51(4):1319–1321. doi: 10.1093/jnci/51.4.1319. [DOI] [PubMed] [Google Scholar]
  10. Oldstone M. B. Immune complexes in cancer: demonstration of complexes in mice bearing neuroblastomas. J Natl Cancer Inst. 1975 Jan;54(1):223–228. doi: 10.1093/jnci/54.1.223. [DOI] [PubMed] [Google Scholar]
  11. Rossen R. D., Reisberg M. A., Hersh E. M., Gutterman J. U. The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst. 1977 May;58(5):1205–1215. doi: 10.1093/jnci/58.5.1205. [DOI] [PubMed] [Google Scholar]
  12. Steele G., Jr, Sonis S., Stelos P., Rittgers R., Zamcheck N., Finn D., Maltz J., Mayer R., Lokich J., Wilson R. E. Circulating immune complexes in patients following clinically curative resection of colorectal cancer. Surgery. 1978 Jun;83(6):648–654. [PubMed] [Google Scholar]
  13. Teshima H., Wanebo H., Pinsky C., Day N. K. Circulating immune complexes detected by 125I-Clq deviation test in sera of cancer patients. J Clin Invest. 1977 Jun;59(6):1134–1142. doi: 10.1172/JCI108737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Theofilopoulos A. N., Andrews B. S., Urist M. M., Morton D. L., Dixon F. J. The nature of immune complexes in human cancer sera. J Immunol. 1977 Aug;119(2):657–663. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES