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. 1981 Jul;104(1):50–54.

IgA glomerular deposits in experimental cirrhosis.

A A Gormly, P S Smith, A E Seymour, A R Clarkson, A J Woodroffe
PMCID: PMC1903743  PMID: 6973280

Abstract

Lewis rats rendered cirrhotic by the administration of carbon tetrachloride developed mesangial and glomerular capillary wall deposits of immunoglobulins (especially IgA) and complement. These rats also had circulating immune complexes and markedly elevated serum IgA concentrations. The model suggests that defective hepatic sequestration of circulating IgA polymers and immune complexes may be responsible for the glomerular deposits. A similar mechanism may account for the high incidence of glomerulonephritis in patients with alcoholic cirrhosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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