Abstract
Severe acute, diffuse lung inflammation was induced in rabbits immunized to bovine serum albumin (BSA) and subsequently challenged with BSA intrapleurally. Evidence suggesting involvement of circulating immune complexes in the pathogenesis of lung injury in these rabbits include 1) positive lung immunofluorescence, 2) a fall in serum hemolytic complement, 3) diffuse bilateral involvement despite unilateral antigen challenge, and 4) absence of these findings in control rabbits. Further investigation with this model may provide insight into the processes involved in the deposition of immune complexes in the lung and the mechanisms of lung injury provoked by immune complex deposition.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brentjens J. R., O'Connell D. W., Pawlowski I. B., Hsu K. C., Andres G. A. Experimental immune complex disease of the lung. The pathogenesis of a laboratory model resembling certain human interstitial lung diseases. J Exp Med. 1974 Jul 1;140(1):105–125. doi: 10.1084/jem.140.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COCHRANE C. G. STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. II. PATHOGENETIC AND PHARMACODYNAMIC STUDIES. J Exp Med. 1963 Oct 1;118:503–513. doi: 10.1084/jem.118.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hunder G. G., McDuffie F. C., Huston K. A., Elveback L. R., Hepper N. G. Pleural fluid complement, complement conversion, and immune complexes in immunologic and nonimmunologic diseases. J Lab Clin Med. 1977 Dec;90(6):971–980. [PubMed] [Google Scholar]
- Jaurand M. C., Kaplan H., Thiollet J., Pinchon M. C., Bernaudin J. F., Bignon J. Phagocytosis of chrysotile fibers by pleural mesothelial cells in culture. Am J Pathol. 1979 Mar;94(3):529–538. [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Richerson H. B. Varieties of acute immunologic damage to the rabbit lung. Ann N Y Acad Sci. 1974;221:340–360. doi: 10.1111/j.1749-6632.1974.tb28236.x. [DOI] [PubMed] [Google Scholar]
- Sahn S. A., Potts D. E. The effect of tetracycline on rabbit pleura. Am Rev Respir Dis. 1978 Mar;117(3):493–499. doi: 10.1164/arrd.1978.117.3.493. [DOI] [PubMed] [Google Scholar]
- Sahn S. A., Potts D. E. Turpentine pleurisy in rabbits: a model of pleural fluid acidosis and low pleural fluid glucose. Am Rev Respir Dis. 1978 Nov;118(5):893–901. doi: 10.1164/arrd.1978.118.5.893. [DOI] [PubMed] [Google Scholar]
- Scherzer H., Ward P. A. Lung and dermal vascular injury produced by preformed immune complexes. Am Rev Respir Dis. 1978 Mar;117(3):551–557. doi: 10.1164/arrd.1978.117.3.551. [DOI] [PubMed] [Google Scholar]
- Scherzer H., Ward P. A. Lung injury produced by immune complexes of varying composition. J Immunol. 1978 Sep;121(3):947–952. [PubMed] [Google Scholar]
- Stauffer J. L., Potts D. E., Sahn S. A. Cellular content of the normal rabbit pleural space. Acta Cytol. 1978 Nov-Dec;22(6):570–574. [PubMed] [Google Scholar]