Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1981 Dec;105(3):295–305.

BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution.

M J Muirhead, P C Isakson, K A Krolick, J W Uhr, E S Vitetta
PMCID: PMC1903899  PMID: 7032308

Abstract

BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectomized transplant recipient. The immunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicate a striking dependence of BCL1 on microenvironmental influences of the host lymphoid tissues.

Full text

PDF
295

Images in this article

298Figure 1
on p.298
298Figure 2
on p.298

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S. A., Isakson P. C., Puré E., Muirhead M., Uhr J. W., Vitetta E. S. Immunosuppression in a murine B cell leukemia (BCL1): role of an adherent cell in the suppression of primary in vitro antibody responses. J Immunol. 1981 Apr;126(4):1603–1607. [PubMed] [Google Scholar]
  2. Bearman R. M., Pangalis G. A., Rappaport H. Prolymphocytic leukemia: clinical, histopathological, and cytochemical observations. Cancer. 1978 Nov;42(5):2360–2372. doi: 10.1002/1097-0142(197811)42:5<2360::aid-cncr2820420537>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  3. Catovsky D. Hairy-cell leukaemia and prolymphocytic leukaemia. Clin Haematol. 1977 Feb;6(1):245–268. [PubMed] [Google Scholar]
  4. GESNER B. M., GOWANS J. L. The output of lymphocytes from the thoracic duct of unanaesthetized mice. Br J Exp Pathol. 1962 Aug;43:424–430. [PMC free article] [PubMed] [Google Scholar]
  5. Galton D. A., Goldman J. M., Wiltshaw E., Catovsky D., Henry K., Goldenberg G. J. Prolymphocytic leukaemia. Br J Haematol. 1974 May;27(1):7–23. doi: 10.1111/j.1365-2141.1974.tb06769.x. [DOI] [PubMed] [Google Scholar]
  6. Isakson P. C., Uhr J. W., Krolick K. A., Finkelman F., Vitetta E. S. Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1. J Exp Med. 1980 Mar 1;151(3):749–754. doi: 10.1084/jem.151.3.749. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Katayama I., Aiba M., Pechet L., Sullivan J. L., Roberts P., Humphreys R. E. B-lineage prolymphocytic leukemia as a distinct clinicopathologic entity. Am J Pathol. 1980 May;99(2):399–412. [PMC free article] [PubMed] [Google Scholar]
  8. Knapp M. R., Jones P. P., Black S. J., Vitetta E. S., Slavin S., Strober S. Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR. J Immunol. 1979 Sep;123(3):992–999. [PubMed] [Google Scholar]
  9. Kotzin B. L., Strober S. Role of the spleen in the growth of a murine B cell leukemia. Science. 1980 Apr 4;208(4439):59–61. doi: 10.1126/science.6965803. [DOI] [PubMed] [Google Scholar]
  10. Krolick K. A., Isakson P. C., Uhr J. W., Vitetta E. S. BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor. Immunol Rev. 1979;48:81–106. doi: 10.1111/j.1600-065x.1979.tb00299.x. [DOI] [PubMed] [Google Scholar]
  11. Krolick K. A., Isakson P. C., Uhr J. W., Vitetta E. S. Murine B cell leukemia (BCL1): organ distribution and kinetics of growth as determined by fluorescence analysis with an anti-idiotypic antibody. J Immunol. 1979 Nov;123(5):1928–1935. [PubMed] [Google Scholar]
  12. Krolick K. A., Villemez C., Isakson P., Uhr J. W., Vitetta E. S. Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5419–5423. doi: 10.1073/pnas.77.9.5419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. König E., Meusers P., Brittinger G. Efficacy of doxorubicin in prolymphocytic leukaemia. Br J Haematol. 1979 Jul;42(3):487–488. doi: 10.1111/j.1365-2141.1979.tb01158.x. [DOI] [PubMed] [Google Scholar]
  14. Ledbetter J. A., Herzenberg L. A. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979;47:63–90. doi: 10.1111/j.1600-065x.1979.tb00289.x. [DOI] [PubMed] [Google Scholar]
  15. Ledbetter J. A., Rouse R. V., Micklem H. S., Herzenberg L. A. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med. 1980 Aug 1;152(2):280–295. doi: 10.1084/jem.152.2.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ligler F., Vitetta E. S., Uhr J. W. Cell surface immunoglobulin. XXII. Reappearance of surface IgM and IgD on murine splenocytes after removal by capping. J Immunol. 1977 Oct;119(4):1545–1546. [PubMed] [Google Scholar]
  17. Puré E., Vitetta E. S. The murine B cell response to TNP-polyacrylamide beads: the relationship between the epitope density of the antigen and the requirements for T cell help and surface IgD. J Immunol. 1980 Jul;125(1):420–427. [PubMed] [Google Scholar]
  18. Shevach E. M., Ellman L., Davie J. M., Green I. L2C Guinea pig lymphatic leukemia: a "B" cell leukemia. Blood. 1972 Jan;39(1):1–12. [PubMed] [Google Scholar]
  19. Sibbald R., Catovsky D. Complete remission in prolymphocytic leukaemia with the combination chemotherapy---CHOP. Br J Haematol. 1979 Jul;42(3):488–490. doi: 10.1111/j.1365-2141.1979.tb01159.x. [DOI] [PubMed] [Google Scholar]
  20. Slavin S., Morecki S., Weiss L. The role of the spleen in tumor growth kinetics of the murine B cell leukemia (BCL1). J Immunol. 1980 Feb;124(2):586–589. [PubMed] [Google Scholar]
  21. Slavin S., Strober S. Spontaneous murine B-cell leukaemia. Nature. 1978 Apr 13;272(5654):624–626. doi: 10.1038/272624a0. [DOI] [PubMed] [Google Scholar]
  22. Strober S., Gronowicz E. S., Knapp M. R., Slavin S., Vitetta E. S., Warnke R. A., Kotzin B., Schröder J. Immunobiology of a spontaneous murine B cell leukemia (BCL1). Immunol Rev. 1979;48:169–195. doi: 10.1111/j.1600-065x.1979.tb00303.x. [DOI] [PubMed] [Google Scholar]
  23. Vitetta E. S., Forman J., Kettman J. R. Cell surface immunoglobulin. XVIII. Functional differences of B lymphocytes bearing different surface immunoglobulin isotypes. J Exp Med. 1976 May 1;143(5):1055–1065. doi: 10.1084/jem.143.5.1055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Vitetta E. S., Yuan D., Krolick K., Isakson P., Knapp M., Slavin S., Strober S. Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody. J Immunol. 1979 May;122(5):1649–1654. [PubMed] [Google Scholar]
  25. Warnke R. A., Slavin S., Coffman R. L., Butcher E. C., Knapp M. R., Strober S., Weissman I. L. The pathology and homing of a transplantable murine B cell leukemia (BCL1). J Immunol. 1979 Sep;123(3):1181–1188. [PubMed] [Google Scholar]
  26. Zan-Bar I., Strober S., Vitetta E. S. The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen. J Exp Med. 1977 May 1;145(5):1188–1205. doi: 10.1084/jem.145.5.1188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. de Sousa M. Lymphocyte maldistribution and immunodeficiency. Hosp Pract. 1980 Jul;15(7):71–87. doi: 10.1080/21548331.1980.11946631. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES