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. 1973 May;71(2):207–218.

Schistosoma mansoni Infection in Mice Depleted of Thymus-Dependent Lymphocytes

II. Pathology and Altered Pathogenesis

Richard D Buchanan, Douglas P Fine, Daniel G Colley
PMCID: PMC1903958  PMID: 4541346

Abstract

Murine schistosomiasis mansoni is a more rapidly fatal disease in hosts deprived of their cell-mediated immune capabilities. Analysis of the histopathology of the disease under these circumstances indicates that rather than the hepatic granulomata characteristic of the normal infection, the host develops zones of liquefactive necrosis in the liver and intestinal mucosa. These lesions are associated with severe parenchymal cell destruction. Such hepatic and mucosal damage, with subsequent toxemia and septicemia, is presumed central to the altered course of the disease.

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Selected References

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