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. 1973 May;71(2):193–206.

Schistosoma mansoni Infection in Mice Depleted of Thymus-Dependent Lymphocytes

I. Eosinophilia and Immunologic Responses to a Schistosomal Egg Preparation

Douglas P Fine, Richard D Buchanan, Daniel G Colley
PMCID: PMC1903959  PMID: 4541345

Abstract

Chronic murine schistosomiasis is characterized by a host cell-mediated immune response to schistosomal egg antigens. This response is manifested in vitro by lymphocyte blastogenic reactivity to a soluble schistosomal egg antigen preparation (SEA) and in vivo by delayed dermal hypersensitivity to SEA. In addition, mice develop reaginic, agglutinating, and early dermal reactive antibodies to SEA and a characteristic pattern of peripheral blood eosinophilia. In this study, depletion of thymus-dependent lymphocytes abolished the anti-SEA lymphocyte blastogenic response and delayed dermal reactivity, reaginic antibody response and the major peak of peripheral blood eosinophilia, which in normal mice occurs at the same time as SEA-induced blastogenesis. Antibodies mediating the early dermal reaction to SEA and agglutinins for SEA-coated particles were not inhibited by T-lymphocyte depletion. The experimental group did not develop the normally observed granulomatous response, but rather suffered focal hepatic and mucosal liquefactive necrosis, bacteremia and accelerated mortality.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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