Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1973 Nov;73(2):425–442.

Venezuelan Equine Encephalomyelitis in an Adult Animal Host

An Electron Microscopic Study

Leo Gorelkin
PMCID: PMC1904063  PMID: 4796626

Abstract

Adult white mice were inoculated intravenously with a virulent strain of Venzuelan equine encephalomyelitis virus. They were sacrificed sequentially, and cerebral tissue was collected for light and electron microscopic examination and virus titer determination. Viruses were first seen on the fifth day postinoculation infecting and arising from endothelial cells in the cerebrum. Subsequently, oligodendrocytes became infected, giving rise to mature virions. At this time in the infection, a particular electron-dense cell, probably representing a glial cell type, phagocytized mature virions. This resulted in autoinfection, as seen by viral growth in and destruction of these dense cells at a later stage of the infection.

Full text

PDF
425

Images in this article

435Fig 5
on p.435
436Fig 6
on p.436
436Fig 7
on p.436
437Fig 8
on p.437
438Fig 9
on p.438
439Fig 10
on p.439
439Fig 11
on p.439
440Fig 12
on p.440
440Fig 13
on p.440
441Fig 14
on p.441
433Fig 1
on p.433
433Fig 2
on p.433
442Fig 15
on p.442
442Fig 16
on p.442
434Fig 3
on p.434
434Fig 4
on p.434

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albrecht P. Pathogenesis of neurotropic arbovirus infections. Curr Top Microbiol Immunol. 1968;43:44–91. doi: 10.1007/978-3-642-46118-7_2. [DOI] [PubMed] [Google Scholar]
  2. Bykovsky A. F., Yershov F. I., Zhdanov V. M. Morphogenesis of Venezuelan equine encephalomyelitis virus. J Virol. 1969 Oct;4(4):496–504. doi: 10.1128/jvi.4.4.496-504.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cole C. A., Nathanson N., Rivet H. Viral hemorrhagic encephalopathy of rats. II. Pathogenesis of central nervous system lesions. Am J Epidemiol. 1970 Mar;91(3):339–350. doi: 10.1093/oxfordjournals.aje.a121144. [DOI] [PubMed] [Google Scholar]
  4. GLEISER C. A., GOCHENOUR W. S., Jr, BERGE T. O., TIGERTT W. D. The comparative pathology of experimental Venezuelan equine encephalomyelitis infection in different animal hosts. J Infect Dis. 1962 Jan-Feb;110:80–97. doi: 10.1093/infdis/110.1.80. [DOI] [PubMed] [Google Scholar]
  5. JOHNSON R. T. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING. J Exp Med. 1964 Feb 1;119:343–356. doi: 10.1084/jem.119.2.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JOHNSON R. T. VIRUS INVASION OF THE CENTRAL NERVOUS SYSTEM: A STUDY OF SINDBIS VIRUS INFECTION IN THE MOUSE USING FLUORESCENT ANTIBODY. Am J Pathol. 1965 Jun;46:929–943. [PMC free article] [PubMed] [Google Scholar]
  7. Kundin W. D., Liu C., Rodina P. Pathogenesis of Venezuelan equine encephalomyelitis virus. I. Infection in suckling mice. J Immunol. 1966 Jan;96(1):39–48. [PubMed] [Google Scholar]
  8. MIMS C. A. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES. Bacteriol Rev. 1964 Mar;28:30–71. doi: 10.1128/br.28.1.30-71.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MIMS C. A. The invasion of the brain by yellow fever virus present in the blood of mice. Br J Exp Pathol. 1957 Jun;38(3):329–338. [PMC free article] [PubMed] [Google Scholar]
  10. Mori S., Leblond C. P. Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats. J Comp Neurol. 1970 May;139(1):1–28. doi: 10.1002/cne.901390102. [DOI] [PubMed] [Google Scholar]
  11. Murphy F. A., Whitfield S. G. Eastern equine encephalitis virus infection: electron microscopic studies of mouse central nervous system. Exp Mol Pathol. 1970 Oct;13(2):131–146. doi: 10.1016/0014-4800(70)90001-8. [DOI] [PubMed] [Google Scholar]
  12. Nathanson N., Cole G. A. Immunosuppression and experimental virus infection of the nervous system. Adv Virus Res. 1970;16:397–448. doi: 10.1016/S0065-3527(08)60028-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rabin E. R., Jenson A. B. Electron microscopic studies of animal viruses with emphasis on in vivo infections. Prog Med Virol. 1967;9:392–450. [PubMed] [Google Scholar]
  14. Randall R., Mills J. W. FATAL ENCEPHALITIS IN MAN DUE TO THE VENEZUELAN VIRUS OF EQUINE ENCEPHALOMYELITIS IN TRINIDAD. Science. 1944 Mar 17;99(2568):225–226. doi: 10.1126/science.99.2568.225. [DOI] [PubMed] [Google Scholar]
  15. TASKER J. B., MIESSE M. L., BERGE T. O. Studies on the virus of Venezuelan equine encephalomyelitis. III. Distribution in tissues of experimentally infected mice. Am J Trop Med Hyg. 1962 Nov;11:844–850. doi: 10.4269/ajtmh.1962.11.844. [DOI] [PubMed] [Google Scholar]
  16. Tsai K., Karstad L. The pathogenesis of epizootic hemorrhagic disease of deer: an electron microscopic study. Am J Pathol. 1973 Mar;70(3):379–400. [PMC free article] [PubMed] [Google Scholar]
  17. Vaughn J. E., Peters A. A third neuroglial cell type. An electron microscopic study. J Comp Neurol. 1968 Jun;133(2):269–288. doi: 10.1002/cne.901330207. [DOI] [PubMed] [Google Scholar]
  18. Weinstein R. S., McNutt N. S. Current concepts. cell junctions. N Engl J Med. 1972 Mar 9;286(10):521–524. doi: 10.1056/NEJM197203092861006. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES