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. 1973 Dec;73(3):711–726.

Cytologic Changes in Dog Lungs Induced by Chronic Exposure to Ozone

Robert J Stephens, Gustave Freeman, Jerry F Stara, David L Coffin
PMCID: PMC1904089  PMID: 4767259

Abstract

Beagle dogs exposed for 8 hours a day to 3 ppm O3 for 18 months showed cytologic changes that indicate metabolic alterations. The endoplasmic reticulum of the type 2 alveolar epithelial cells in the proximal alveoli were frequently dilated and contained a moderately electron-dense substance having a periodicity of approximately 754 A. This condition was accompanied by a substantial reduction in the lamellar membranes in the characteristic lamellar bodies of the type 2 cells, suggesting a sequestering of protein in the endoplasmic reticulum. In addition, endothelial cells contained paracrystalline arrays of cytoplasmic membranes not observed in control animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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