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. 1996 Jul;70(7):4787–4790. doi: 10.1128/jvi.70.7.4787-4790.1996

Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination.

C M Gelder 1, J R Lamb 1, B A Askonas 1
PMCID: PMC190418  PMID: 8676508

Abstract

We have examined human CD4+ T-cell recognition of influenza A/Beijing/32/92 (H3N2) virus hemagglutinin following influenza virus HANA subunit vaccination. CD4+ T-cell repertoires were dominated by recognition of epitopes located in conserved regions of the molecule, in a major histocompatibility complex class II haplotype-dependent manner, analogous to that observed following natural infection.

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Selected References

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  1. Anders E. M., Peppard P. M., Burns W. H., White D. O. In vitro antibody response to influenza virus. I. T cell dependence of secondary response to hemagglutinin. J Immunol. 1979 Sep;123(3):1356–1361. [PubMed] [Google Scholar]
  2. Askonas B. A. T-cell differentiation and effector functions. Immunol Suppl. 1988;1:51–52. [PubMed] [Google Scholar]
  3. Biddison W. E., Sharrow S. O., Shearer G. M. T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: evidence for T cell help. J Immunol. 1981 Aug;127(2):487–491. [PubMed] [Google Scholar]
  4. Both G. W., Sleigh M. J., Cox N. J., Kendal A. P. Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. J Virol. 1983 Oct;48(1):52–60. doi: 10.1128/jvi.48.1.52-60.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Braakman E., Treep-Van Leeuwen P., Roosnek E. E., Lucas C. J. The role of IL-2 and T4+ cells in the generation of human influenza virus-specific CTL activity. Cell Immunol. 1986 Jul;100(2):462–473. doi: 10.1016/0008-8749(86)90045-6. [DOI] [PubMed] [Google Scholar]
  6. Burns W., Billups L. C., Notkins A. L. Thymus dependence of viral antigens. Nature. 1975 Aug 21;256(5519):654–656. doi: 10.1038/256654a0. [DOI] [PubMed] [Google Scholar]
  7. Gelder C. M., Welsh K. I., Faith A., Lamb J. R., Askonas B. A. Human CD4+ T-cell repertoire of responses to influenza A virus hemagglutinin after recent natural infection. J Virol. 1995 Dec;69(12):7497–7506. doi: 10.1128/jvi.69.12.7497-7506.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lightman S., Cobbold S., Waldmann H., Askonas B. A. Do L3T4+ T cells act as effector cells in protection against influenza virus infection. Immunology. 1987 Sep;62(1):139–144. [PMC free article] [PubMed] [Google Scholar]
  9. McMichael A. Cytotoxic T lymphocytes specific for influenza virus. Curr Top Microbiol Immunol. 1994;189:75–91. doi: 10.1007/978-3-642-78530-6_5. [DOI] [PubMed] [Google Scholar]
  10. Virelizier J. L., Postlethwaite R., Schild G. C., Allison A. C. Antibody responses to antigenic determinants of influenza virus hemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory. J Exp Med. 1974 Dec 1;140(6):1559–1570. doi: 10.1084/jem.140.6.1559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Webster R. G., Laver W. G., Air G. M., Schild G. C. Molecular mechanisms of variation in influenza viruses. Nature. 1982 Mar 11;296(5853):115–121. doi: 10.1038/296115a0. [DOI] [PubMed] [Google Scholar]
  12. Wiley D. C., Wilson I. A., Skehel J. J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature. 1981 Jan 29;289(5796):373–378. doi: 10.1038/289373a0. [DOI] [PubMed] [Google Scholar]

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