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. 1996 Jul;70(7):4800–4804. doi: 10.1128/jvi.70.7.4800-4804.1996

A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.

A Fernandez-Sesma 1, J L Schulman 1, T M Moran 1
PMCID: PMC190421  PMID: 8676511

Abstract

Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.

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Selected References

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