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. 1996 Jul;70(7):4845–4848. doi: 10.1128/jvi.70.7.4845-4848.1996

The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.

S Sieg 1, C King 1, Y Huang 1, D Kaplan 1
PMCID: PMC190430  PMID: 8676520

Abstract

We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.

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Selected References

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