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. 1996 Aug;70(8):4914–4918. doi: 10.1128/jvi.70.8.4914-4918.1996

AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.

W Guo 1, W J Tang 1, X Bu 1, V Bermudez 1, M Martin 1, W R Folk 1
PMCID: PMC190441  PMID: 8763994

Abstract

An early step in the initiation of polyomavirus DNA replication is viral large-T-antigen-mediated unwinding of the origin. We report that components of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provides a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.

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Selected References

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