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. 1996 Sep;70(9):6446–6449. doi: 10.1128/jvi.70.9.6446-6449.1996

DNA double-strand break repair functions defend against parvovirus infection.

T J Tauer 1, M H Schneiderman 1, J K Vishwanatha 1, S L Rhode 1
PMCID: PMC190677  PMID: 8709279

Abstract

We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.

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Selected References

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