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. 1996 Sep;70(9):6516–6518. doi: 10.1128/jvi.70.9.6516-6518.1996

Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice.

E J Usherwood 1, J P Stewart 1, A A Nash 1
PMCID: PMC190690  PMID: 8709292

Abstract

Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.

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Selected References

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