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. 1964 Sep;45(3):353–379.

Ultrastructural Changes Produced by Protein and Related Deficiencies in the Rat Liver

Donald Svoboda, John Higginson
PMCID: PMC1907079  PMID: 14212804

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON J. B. Protein malnutrition. Trans N Y Acad Sci. 1963 Jan;25:293–306. doi: 10.1111/j.2164-0947.1963.tb01224.x. [DOI] [PubMed] [Google Scholar]
  2. BERNHARD W., ROUILLER C. Close topographical relationship between mitochondria and ergastoplasm of liver cells in a definite phase of cellular activity. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):73–78. doi: 10.1083/jcb.2.4.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CAMAIN R., ROUILLER C., DUPIN H. Evolution de la stéatose hépatique dans le kwashiorkor sous l'influence du régime hyperprotidique; étude en microscopie normale et électronique. Ann Anat Pathol (Paris) 1959 Apr-Jun;4(2):220–241. [PubMed] [Google Scholar]
  4. CHRISTIE G. S., JUDAH J. D. Intracellular distribution of enzymes. Proc R Soc Lond B Biol Sci. 1953 Jul 15;141(904):420–433. doi: 10.1098/rspb.1953.0051. [DOI] [PubMed] [Google Scholar]
  5. DAVID H., LUNZENAUER K., BARTOK I. [The effect of long-term albumin-deficient diet and chronic CC14 poisoning on the submicroscopic picture of rat liver]. Z Gesamte Inn Med. 1962 Nov 15;17:993–999. [PubMed] [Google Scholar]
  6. ELY J. O., ROSS M. H. Desoxyribonucleic acid content of rat liver nuclei influenced by diet. Science. 1951 Jul 20;114(2951):70–73. doi: 10.1126/science.114.2951.70. [DOI] [PubMed] [Google Scholar]
  7. FARBER E., BUEDING E. Histochemical localization of specific oxidative enzymes. V. The dissociation of succinic dehydrogenase from carriers by lipase and the specific histochemical localization of the dehydrogenase with phenazine methosulfate and tetrazolium salts. J Histochem Cytochem. 1956 Jul;4(4):357–362. doi: 10.1177/4.4.357. [DOI] [PubMed] [Google Scholar]
  8. FARBER E., LOMBARDI B., CASTILLO A. E. THE PREVENTION BY ADENOSINE TRIPHOSPHATE OF THE FATTY LIVER INDUCED BY ETHIONINE. Lab Invest. 1963 Sep;12:873–883. [PubMed] [Google Scholar]
  9. FAWCETT D. W. The membranes of the cytoplasm. Lab Invest. 1961 Nov-Dec;10:1162–1188. [PubMed] [Google Scholar]
  10. GRISHAM J. W., BANSON B. B., HARTROFT W. S. Nuclear and nucleolar alterations in hepatic parenchymal cells of the choline-deficient rat. I. Volume changes. Arch Pathol. 1960 Jul;70:50–58. [PubMed] [Google Scholar]
  11. HIGGINSON J. THE GEOGRAPHICAL PATHOLOGY OF PRIMARY LIVER CANCER. Cancer Res. 1963 Nov;23:1624–1633. [PubMed] [Google Scholar]
  12. JEZEQUEL A. M. [Myelin degeneration of the mitochondria of the human liver in epithelioma of the choledochus and in viral jaundice. Study with the electron microscope]. J Ultrastruct Res. 1959 Dec;3:210–215. doi: 10.1016/s0022-5320(59)90015-2. [DOI] [PubMed] [Google Scholar]
  13. Kosterlitz H. W. The effects of changes in dietary protein on the composition and structure of the liver cell. J Physiol. 1947 Jun 2;106(2):194–210.1. [PMC free article] [PubMed] [Google Scholar]
  14. NACHLAS M. M., TSOU K. C., DE SOUZA E., CHENG C. S., SELIGMAN A. M. Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole. J Histochem Cytochem. 1957 Jul;5(4):420–436. doi: 10.1177/5.4.420. [DOI] [PubMed] [Google Scholar]
  15. NOVIKOFF A. B. A transplantable rat liver tumor induced by 4-dimethylaminoazobenzene. Cancer Res. 1957 Nov;17(10):1010–1027. [PubMed] [Google Scholar]
  16. ROUILLER C. Les canalicules biliaires; etude au microscope électronique. Acta Anat (Basel) 1956;26(2):94–109. [PubMed] [Google Scholar]
  17. SCOTT E. B. Histopathology of amino acid deficiencies. VI. Effect of arginine deficiency on the liver, with consideration of the testes and accessory sex glands. Arch Pathol. 1960 Apr;69:390–401. [PubMed] [Google Scholar]
  18. SIDRANSKY H., BABA T. Chemical pathology of acute amino acid deficiencies. III. Morphologic and biochemical changes in young rats fed valine- or lysine-devoid diets. J Nutr. 1960 Apr;70:463–483. doi: 10.1093/jn/70.4.463. [DOI] [PubMed] [Google Scholar]
  19. SIDRANSKY H., CLARK S. Chemical pathology of acute amino acid deficiencies. IV. Influence of carbohydrate intake on the morphologic and biochemical changes in young rats fed threonine- or valine-devoid diets. Arch Pathol. 1961 Oct;72:468–479. [PubMed] [Google Scholar]
  20. SIDRANSKY H. Chemical pathology of nutritional deficiency induced by certain plant proteins. J Nutr. 1960 Aug;71:387–399. doi: 10.1093/jn/71.4.387. [DOI] [PubMed] [Google Scholar]
  21. SIDRANSKY H., FARBER E. Chemical pathology of acute amino acid deficiencies. II. Biochemical changes in rats fed threonine-or methionine-devoid diets. AMA Arch Pathol. 1958 Aug;66(2):135–149. [PubMed] [Google Scholar]
  22. STEINER J. W., CARRUTHERS J. S. Electron microscopy of hyperplastic ductular cells in alpha-naphthyl isothiocyanateinduced cirrhosis. Lab Invest. 1963 Apr;12:471–498. [PubMed] [Google Scholar]
  23. STENGER R. J. HEPATIC PARENCHYMAL CELL ALTERATIONS AFTER LONG-TERM CARBON TETRACHLORIDE ADMINISTRATION. A LIGHT AND ELECTRON MICROSCOPIC STUDY. Am J Pathol. 1963 Nov;43:867–895. [PMC free article] [PubMed] [Google Scholar]
  24. STENRAM U. Nucleolar size in the liver of rats fed on high and nonprotein diets after starvation. Acta Anat (Basel) 1956;26(4):352–360. doi: 10.1159/000141108. [DOI] [PubMed] [Google Scholar]
  25. STENRAM U. The volume and ribose nucleic acid concentration of nucleoli in liver and hepatoma cells of rats fed on high and non protein diets. Acta Pathol Microbiol Scand. 1958;44(3):239–246. doi: 10.1111/j.1699-0463.1958.tb01073.x. [DOI] [PubMed] [Google Scholar]
  26. STOECKENIUS W. Electron microscopy of DNA molecules "stained" with heavy metal salts. J Biophys Biochem Cytol. 1961 Nov;11:297–310. doi: 10.1083/jcb.11.2.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SVOBODA D. J., HIGGINSON J. ULTRASTRUCTURAL HEPATIC CHANGES IN RATS ON A NECROGENIC DIET. Am J Pathol. 1963 Sep;43:477–495. [PMC free article] [PubMed] [Google Scholar]
  28. SVOBODA D. J. Ultrastructure of pulmonary adenomas in mice. Cancer Res. 1962 Nov;22:1197–1201. [PubMed] [Google Scholar]
  29. SVOBODA D., NIELSON A., WERBER A., HIGGINSON J. An electron microscopic study of viral hepatitis in mice. Am J Pathol. 1962 Aug;41:205–224. [PMC free article] [PubMed] [Google Scholar]
  30. Svoboda D. J., Manning R. T. Chronic alcoholism with fatty metamorphosis of the liver. Mitochondrial alterations in hepatic cells. Am J Pathol. 1964 Apr;44(4):645–662. [PMC free article] [PubMed] [Google Scholar]
  31. THERON J. J., LIEBENBERG N. Some observations on the fine cytology of the parenchymal liver cells in kwashiorkor patients. J Pathol Bacteriol. 1963 Jul;86:109–112. doi: 10.1002/path.1700860113. [DOI] [PubMed] [Google Scholar]
  32. TRUMP B. F., GOLDBLATT P. J., STOWELL R. E. An electron microscopic study of early cytoplasmic alterations in hepatic parenchymal cells of mouse liver during necrosis in vitro (autolysis). Lab Invest. 1962 Nov;11:986–1015. [PubMed] [Google Scholar]
  33. WAINIO W. W., EICHEL B., EICHEL H. J., PERSON P., ESTES F. L., ALLISON J. B. Oxidative enzymes of the liver in protein depletion. J Nutr. 1953 Mar;49(3):465–483. doi: 10.1093/jn/49.3.465. [DOI] [PubMed] [Google Scholar]
  34. WATERLOW J. C. Protein nutrition and enzyme changes in man. Fed Proc. 1959 Dec;18:1143–1155. [PubMed] [Google Scholar]
  35. WILSON J. W., LEDUC E. H. Mitochondrial changes in the liver of essential fatty acid-deficient mice. J Cell Biol. 1963 Feb;16:281–296. doi: 10.1083/jcb.16.2.281. [DOI] [PMC free article] [PubMed] [Google Scholar]

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