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. 1992 Jul;106(3):509–510. doi: 10.1111/j.1476-5381.1992.tb14366.x

(S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor.

R H Porter 1, P J Roberts 1, D E Jane 1, J C Watkins 1
PMCID: PMC1907545  PMID: 1324071

Abstract

The synthetic quisqualate analogue, (S)-homoquisqualate was examined for activity at the glutamate metabotropic receptor, in relation to its ability to stimulate phosphoinositide hydrolysis in rat pup cerebro-cortical slices. The compound produced a robust increase in hydrolysis (EC50 = 50.2 +/- 1.6 microM), which, in common with responses to quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate ((1S,3R)-ACPD), was antagonized uncompetitively by L-2-amino-3-phosphonopropionate (L-AP3). In contrast to quisqualate which exhibits low efficacy, (S)-homoquisqualate behaves as a full agonist at the metabotropic receptor.

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Selected References

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