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. 1992 Aug;106(4):762–763. doi: 10.1111/j.1476-5381.1992.tb14408.x

ATP mediates excitatory synaptic transmission in mammalian neurones.

E M Silinsky 1, V Gerzanich 1, S M Vanner 1
PMCID: PMC1907676  PMID: 1327385

Abstract

Adenosine 5'-triphosphate (ATP, 0.1-100 microM), produced inward currents in patch-clamped coeliac neurones from guinea-pig when studied in either the whole cell configuration or in excised (outside-out) patches. The P2-purinoceptor antagonists suramin (80-230 microM) or reactive blue 2 (2-20 microM) depressed the ATP-induced currents but not those produced by acetylcholine. Excitatory post-synaptic currents (e.p.s.cs) were observed in cultured neurones. E.p.s.cs had similar current-voltage relationships to currents evoked by ATP in excised patches and were reduced by suramin or reactive blue 2 to a similar extent as ATP currents. The results suggest that ATP is the excitatory neurotransmitter in cultures of these neurones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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