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. 1996 Oct;70(10):7213–7218. doi: 10.1128/jvi.70.10.7213-7218.1996

Murine infection with lymphocytic choriomeningitis virus following gastric inoculation.

S K Rai 1, D S Cheung 1, M S Wu 1, T F Warner 1, M S Salvato 1
PMCID: PMC190775  PMID: 8794369

Abstract

Laboratory studies of arenaviruses have been limited to parenteral routes of infection; however, recent epidemiological studies implicate virus ingestion as a natural route of infection. Accordingly, we developed a model for oral and gastric infection with lymphocytic choriomeningitis virus to enable studies of mucosal transmission and vaccination by this additional route.

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Selected References

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  1. Ahmed R., Salmi A., Butler L. D., Chiller J. M., Oldstone M. B. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med. 1984 Aug 1;160(2):521–540. doi: 10.1084/jem.160.2.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Amerongen H. M., Weltzin R., Farnet C. M., Michetti P., Haseltine W. A., Neutra M. R. Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS. J Acquir Immune Defic Syndr. 1991;4(8):760–765. [PubMed] [Google Scholar]
  3. Byrne J. A., Oldstone M. B. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J Virol. 1984 Sep;51(3):682–686. doi: 10.1128/jvi.51.3.682-686.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cash R. A., Alam J., Toaha K. M. Gastric acid secretion in cholera patients. Lancet. 1970 Dec 5;2(7684):1192–1192. doi: 10.1016/s0140-6736(70)90379-x. [DOI] [PubMed] [Google Scholar]
  5. Cerottini J. C., Brunner K. T. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974;18:67–132. doi: 10.1016/s0065-2776(08)60308-9. [DOI] [PubMed] [Google Scholar]
  6. Delmas B., Gelfi J., L'Haridon R., Vogel L. K., Sjöström H., Norén O., Laude H. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV. Nature. 1992 Jun 4;357(6377):417–420. doi: 10.1038/357417a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Di Simone C., Zandonatti M. A., Buchmeier M. J. Acidic pH triggers LCMV membrane fusion activity and conformational change in the glycoprotein spike. Virology. 1994 Feb;198(2):455–465. doi: 10.1006/viro.1994.1057. [DOI] [PubMed] [Google Scholar]
  8. Gilden D. H., Cole G. A., Monjan A. A., Nathanson N. Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. I. Cyclophosphamide-mediated induction by the virus-carrier state in adult mice. J Exp Med. 1972 Apr 1;135(4):860–873. doi: 10.1084/jem.135.4.860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gilden D. H., Cole G. A., Nathanson N. Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. J Exp Med. 1972 Apr 1;135(4):874–889. doi: 10.1084/jem.135.4.874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Klavinskis L. S., Whitton J. L., Oldstone M. B. Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. J Virol. 1989 Oct;63(10):4311–4316. doi: 10.1128/jvi.63.10.4311-4316.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lewicki H., McKee T. A., Tishon A., Salvato M., Whitton J. L., Oldstone M. B. Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease. J Neuroimmunol. 1992 Nov;41(1):15–20. doi: 10.1016/0165-5728(92)90190-v. [DOI] [PubMed] [Google Scholar]
  12. Ludwig G. V., Israel B. A., Christensen B. M., Yuill T. M., Schultz K. T. Role of La Crosse virus glycoproteins in attachment of virus to host cells. Virology. 1991 Apr;181(2):564–571. doi: 10.1016/0042-6822(91)90889-j. [DOI] [PubMed] [Google Scholar]
  13. Lukashevich I. S., Clegg J. C., Sidibe K. Lassa virus activity in Guinea: distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen. J Med Virol. 1993 Jul;40(3):210–217. doi: 10.1002/jmv.1890400308. [DOI] [PubMed] [Google Scholar]
  14. Mackett M., Smith G. L., Moss B. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J Virol. 1984 Mar;49(3):857–864. doi: 10.1128/jvi.49.3.857-864.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Marx P. A., Compans R. W., Gettie A., Staas J. K., Gilley R. M., Mulligan M. J., Yamshchikov G. V., Chen D., Eldridge J. H. Protection against vaginal SIV transmission with microencapsulated vaccine. Science. 1993 May 28;260(5112):1323–1327. doi: 10.1126/science.8493576. [DOI] [PubMed] [Google Scholar]
  16. Miller C. J., McGhee J. R., Gardner M. B. Mucosal immunity, HIV transmission, and AIDS. Lab Invest. 1993 Feb;68(2):129–145. [PubMed] [Google Scholar]
  17. Montali R. J., Scanga C. A., Pernikoff D., Wessner D. R., Ward R., Holmes K. V. A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. J Infect Dis. 1993 Apr;167(4):946–950. doi: 10.1093/infdis/167.4.946. [DOI] [PubMed] [Google Scholar]
  18. Neutra M. R., Kraehenbuhl J. P. Transepithelial transport and mucosal defence I: the role of M cells. Trends Cell Biol. 1992 May;2(5):134–138. doi: 10.1016/0962-8924(92)90099-9. [DOI] [PubMed] [Google Scholar]
  19. Odermatt B., Eppler M., Leist T. P., Hengartner H., Zinkernagel R. M. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8252–8256. doi: 10.1073/pnas.88.18.8252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Parker J. C., Igel H. J., Reynolds R. K., Lewis A. M., Jr, Rowe W. P. Lymphocytic choriomeningitis virus infection in fetal, newborn, and young adult Syrian hamsters (Mesocricetus auratus). Infect Immun. 1976 Mar;13(3):967–981. doi: 10.1128/iai.13.3.967-981.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Siciński P., Rowiński J., Warchoł J. B., Jarzabek Z., Gut W., Szczygieł B., Bielecki K., Koch G. Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology. 1990 Jan;98(1):56–58. doi: 10.1016/0016-5085(90)91290-m. [DOI] [PubMed] [Google Scholar]
  22. Skinner H. H., Knight E. H. Epidermal tissue as a primary site of replication of lymphocytic choriomeningitis virus in small experimental hosts. J Hyg (Lond) 1979 Feb;82(1):21–30. doi: 10.1017/s0022172400025432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Stiehm E. R., Vink P. Transmission of human immunodeficiency virus infection by breast-feeding. J Pediatr. 1991 Mar;118(3):410–412. doi: 10.1016/s0022-3476(05)82157-2. [DOI] [PubMed] [Google Scholar]
  24. Van Loon F. P., Clemens J. D., Shahrier M., Sack D. A., Stephensen C. B., Khan M. R., Rabbani G. H., Rao M. R., Banik A. K. Low gastric acid as a risk factor for cholera transmission: application of a new non-invasive gastric acid field test. J Clin Epidemiol. 1990;43(12):1361–1367. doi: 10.1016/0895-4356(90)90103-v. [DOI] [PubMed] [Google Scholar]
  25. Whitton J. L., Southern P. J., Oldstone M. B. Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology. 1988 Feb;162(2):321–327. doi: 10.1016/0042-6822(88)90471-0. [DOI] [PubMed] [Google Scholar]
  26. Whitton J. L., Tishon A., Lewicki H., Gebhard J., Cook T., Salvato M., Joly E., Oldstone M. B. Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity. J Virol. 1989 Oct;63(10):4303–4310. doi: 10.1128/jvi.63.10.4303-4310.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Wolf J. L., Rubin D. H., Finberg R., Kauffman R. S., Sharpe A. H., Trier J. S., Fields B. N. Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981 Apr 24;212(4493):471–472. doi: 10.1126/science.6259737. [DOI] [PubMed] [Google Scholar]
  28. Zinkernagel R. M., Dunlop M. B., Doherty P. C. Cytotoxic T cell activity is strain-specific in outbred mice infected with lymphocytic choriomeningitis virus. J Immunol. 1975 Dec;115(6):1613–1616. [PubMed] [Google Scholar]
  29. Zinkernagel R. M., Welsh R. M. H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D. J Immunol. 1976 Nov;117(5 Pt 1):1495–1502. [PubMed] [Google Scholar]
  30. zur Hausen H. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology. 1991 Sep;184(1):9–13. doi: 10.1016/0042-6822(91)90816-t. [DOI] [PubMed] [Google Scholar]

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