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. 1992 Dec;107(4):1057–1060. doi: 10.1111/j.1476-5381.1992.tb13406.x

Stereospecific antiarrhythmic effects of naloxone against myocardial ischaemia and reperfusion in the dog.

A Y Lee 1
PMCID: PMC1907928  PMID: 1467828

Abstract

1. The effects of both the (-)- and (+)-stereoisomers of naloxone in anaesthetized dogs with arrhythmias induced by acute coronary artery occlusion followed by reperfusion were investigated. 2. Following coronary artery occlusion and reperfusion, all dogs in the control group developed ischaemia- and reperfusion-induced cardiac arrhythmias, bradycardia and hypotension. 3. The opiate antagonist (-)-naloxone prevented the arrhythmias, bradycardia and hypotension due to myocardial ischaemia and reperfusion. 4. The (+)-stereoisomer of naloxone, which is inactive as an opiate antagonist, was without beneficial effects. 5. These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism.

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Selected References

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  1. Benfey B. G., Elfellah M. S., Ogilvie R. I., Varma D. R. Anti-arrhythmic effects of prazosin and propranolol during coronary artery occlusion and re-perfusion in dogs and pigs. Br J Pharmacol. 1984 Jul;82(3):717–725. doi: 10.1111/j.1476-5381.1984.tb10811.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bergey J. L., Beil M. E. Antiarrhythmic evaluation of naloxone against acute coronary occlusion-induced arrhythmias in pigs. Eur J Pharmacol. 1983 Jun 17;90(4):427–431. doi: 10.1016/0014-2999(83)90566-6. [DOI] [PubMed] [Google Scholar]
  3. Brasch H. Influence of the optical isomers (+)- and (-)-naloxone on beating frequency, contractile force and action potentials of guinea-pig isolated cardiac preparations. Br J Pharmacol. 1986 Aug;88(4):733–740. doi: 10.1111/j.1476-5381.1986.tb16245.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carratu' M. R., Mitolo-Chieppa D. Inhibition of ionic currents in frog node of Ranvier treated with naloxone. Br J Pharmacol. 1982 Sep;77(1):115–119. doi: 10.1111/j.1476-5381.1982.tb09276.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fagbemi O., Leprán I., Parratt J. R., Szekeres L. Naloxone inhibits early arrhythmias resulting from acute coronary ligation. Br J Pharmacol. 1982 Aug;76(4):504–506. doi: 10.1111/j.1476-5381.1982.tb09246.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Huang X. D., Lee A. Y., Wong T. M., Zhan C. Y., Zhao Y. Y. Naloxone inhibits arrhythmias induced by coronary artery occlusion and reperfusion in anaesthetized dogs. Br J Pharmacol. 1986 Mar;87(3):475–477. doi: 10.1111/j.1476-5381.1986.tb10186.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lee A. Y., Chen Y. T., Kan M. N., P'eng F. K., Chai C. Y., Kuo J. S. Consequences of opiate agonist and antagonist in myocardial ischaemia suggest a role of endogenous opioid peptides in ischaemic heart disease. Cardiovasc Res. 1992 Apr;26(4):392–395. doi: 10.1093/cvr/26.4.392. [DOI] [PubMed] [Google Scholar]
  8. Lee A. Y. Endogenous opioid peptides and cardiac arrhythmias. Int J Cardiol. 1990 May;27(2):145–151. doi: 10.1016/0167-5273(90)90152-u. [DOI] [PubMed] [Google Scholar]
  9. Lee A. Y., Wong T. M. Effects of dynorphin1-13 on cardiac rhythm and cyclic adenosine monophosphate (cAMP) levels in the isolated perfused rat heart. Neurosci Lett. 1987 Oct 5;80(3):289–292. doi: 10.1016/0304-3940(87)90469-1. [DOI] [PubMed] [Google Scholar]
  10. Lee A. Y., Zhan C. Y., Wong T. M. Effects of beta-endorphin on the contraction and electrical activity of the isolated perfused rat heart. Int J Pept Protein Res. 1984 Nov;24(5):525–528. doi: 10.1111/j.1399-3011.1984.tb03154.x. [DOI] [PubMed] [Google Scholar]
  11. Lin C. J., Chen Y. T., Kuo J. S., Lee A. Y. Antiarrhythmic action of naloxone. Suppression of picrotoxin-induced cardiac arrhythmias in the rat. Jpn Heart J. 1992 May;33(3):365–372. doi: 10.1536/ihj.33.365. [DOI] [PubMed] [Google Scholar]
  12. Markiewicz K., Kuś W., Cholewa M., Bubiński R. Electrophysiologic effects of blocking and stimulating the opioid system in patients with unexplained heart palpitations. Clin Cardiol. 1991 Oct;14(10):813–820. doi: 10.1002/clc.4960141008. [DOI] [PubMed] [Google Scholar]
  13. Parratt J. R., Sitsapesan R. Stereospecific antiarrhythmic effect of opioid receptor antagonists in myocardial ischaemia. Br J Pharmacol. 1986 Apr;87(4):621–622. doi: 10.1111/j.1476-5381.1986.tb14577.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Penny W. J., Sheridan D. J. Arrhythmias and cellular electrophysiological changes during myocardial "ischaemia" and reperfusion. Cardiovasc Res. 1983 Jun;17(6):363–372. doi: 10.1093/cvr/17.6.363. [DOI] [PubMed] [Google Scholar]
  15. Sakamoto S., Stone C. K., Woolf P. D., Liang C. S. Opiate receptor antagonism in right-sided congestive heart failure. Naloxone exerts salutary hemodynamic effects through its action on the central nervous system. Circ Res. 1989 Jul;65(1):103–114. doi: 10.1161/01.res.65.1.103. [DOI] [PubMed] [Google Scholar]
  16. Sarne Y., Hochman I., Eshed M., Oppenheimer E. Antiarrhythmic action of naloxone: direct, non-opiate effect on the rat heart. Life Sci. 1988;43(10):859–864. doi: 10.1016/0024-3205(88)90513-9. [DOI] [PubMed] [Google Scholar]
  17. Zhan Z. Y., Lee A. Y., Wong T. M. Naloxone blocks the cardiac effects of myocardial ischaemia and reperfusion in the rat isolated heart. Clin Exp Pharmacol Physiol. 1985 Jul-Aug;12(4):373–378. doi: 10.1111/j.1440-1681.1985.tb00885.x. [DOI] [PubMed] [Google Scholar]

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