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. 1992 Dec;107(4):1135–1139. doi: 10.1111/j.1476-5381.1992.tb13419.x

Effects of cicletanine on haemodynamics, arrhythmias and extent of necrosis during coronary ligation in rabbits.

T Burton 1, S Chakrabarty 1, D S Fluck 1, N A Flores 1, D J Sheridan 1
PMCID: PMC1907940  PMID: 1467835

Abstract

1. The effects of cicletanine on arrhythmias, haemodynamics and extent of necrosis during myocardial ischaemia were investigated in rabbits subjected to coronary ligation. 2. Cicletanine increased cardiac output prior to coronary occlusion (P < 0.01) but had no other significant haemodynamic effects at this time and did not significantly alter heart rate, blood pressure or cardiac output during 30 min of ischaemia or 30 min of reperfusion. 3. Ventricular fibrillation and mortality were greater in control (65% and 60% respectively) than treated animals (15.4% and 15.4%, P < 0.01). 4. The extent of myocardial necrosis expressed as a percentage of the area at risk was also reduced by cicletanine from 61 +/- 8% in controls to 37 +/- 6% (P < 0.05). 5. These findings indicate that cicletanine attenuates arrhythmias and preserves myocardium in the early phase of ischaemia and this effect appears to be independent of an established antihypertensive action.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Araki H., Lefer A. M. Role of prostacyclin in the preservation of ischemic myocardial tissue in the perfused cat heart. Circ Res. 1980 Nov;47(5):757–763. doi: 10.1161/01.res.47.5.757. [DOI] [PubMed] [Google Scholar]
  2. Auguet M., Delaflotte S., Hellegouarch A., Guillon J. M., Baranes J., Pirotzky E., Clostre F., Braquet P. In vitro cardiovascular antihistamine properties of cicletanine in comparison with diphenhydramine. Drugs Exp Clin Res. 1988;14(2-3):149–153. [PubMed] [Google Scholar]
  3. Bourgain R. H., Deby C., Andries R. Effet du ciclétanine sur la génération de prostacycline in vivo. Arch Mal Coeur Vaiss. 1989 Nov;82(SPEC):33–36. [PubMed] [Google Scholar]
  4. Coker S. J., Parratt J. R. AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion-induced arrhythmias in anaesthetized greyhounds. Br J Pharmacol. 1985 Sep;86(1):259–264. doi: 10.1111/j.1476-5381.1985.tb09457.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dorian B., Larrue J., Defeudis F. V., Salari H., Borgeat P., Braquet P. Activation of prostacyclin synthesis in cultured aortic smooth muscle cells by 'diuretic-antihypertensive' drugs. Biochem Pharmacol. 1984 Jul 15;33(14):2265–2269. doi: 10.1016/0006-2952(84)90665-8. [DOI] [PubMed] [Google Scholar]
  6. Flores N. A., Davies R. L., Penny W. J., Sheridan D. J. Coronary microangiography in the guinea pig, rabbit and ferret. Int J Cardiol. 1984 Oct;6(4):459–471. doi: 10.1016/0167-5273(84)90326-7. [DOI] [PubMed] [Google Scholar]
  7. Fodor G. P., Guinot P. Review of three studies to determine the efficacy and tolerance of cicletanine in the short- and long-term treatment of essential hypertension. Drugs Exp Clin Res. 1988;14(2-3):195–204. [PubMed] [Google Scholar]
  8. Garay R. P., Nazaret C., Diez J., Etienne A., Bourgain R., Braquet P., Esanu A. Stimulation of K+ fluxes by diuretic drugs in human red cells. Biochem Pharmacol. 1984 Jul 1;33(13):2013–2020. doi: 10.1016/0006-2952(84)90567-7. [DOI] [PubMed] [Google Scholar]
  9. Jouve R., Langlet F., Puddu P. E., Rolland P. H., Guillen J. C., Cano J. P., Serradimigni A. Cicletanide improves outcome after left circumflex coronary artery occlusion-reperfusion in the dog. J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):208–215. doi: 10.1097/00005344-198601000-00030. [DOI] [PubMed] [Google Scholar]
  10. Karmazyn M. Contribution of prostaglandins to reperfusion-induced ventricular failure in isolated rat hearts. Am J Physiol. 1986 Jul;251(1 Pt 2):H133–H140. doi: 10.1152/ajpheart.1986.251.1.H133. [DOI] [PubMed] [Google Scholar]
  11. Koltai M., Tosaki A., Berthet P., Tarrade T., Esanu A., Braquet P. Effect of cicletanine on reperfusion-induced arrhythmias and myocardial ion contents: a comparison with furosemide. Eur Heart J. 1992 Mar;13(3):395–403. doi: 10.1093/oxfordjournals.eurheartj.a060180. [DOI] [PubMed] [Google Scholar]
  12. Levy B. I., Curmi P., Poitevin P., Safar M. E. Modifications of the arterial mechanical properties of normotensive and hypertensive rats without arterial pressure changes. J Cardiovasc Pharmacol. 1989 Aug;14(2):253–259. doi: 10.1097/00005344-198908000-00011. [DOI] [PubMed] [Google Scholar]
  13. Moffat M. P. Concentration-dependent effects of prostacyclin on the response of the isolated guinea pig heart to ischemia and reperfusion: possible involvement of the slow inward current. J Pharmacol Exp Ther. 1987 Jul;242(1):292–299. [PubMed] [Google Scholar]
  14. Parratt J. R., Coker S. J. Arachidonic acid cascade and the generation of ischemia- and reperfusion-induced ventricular arrhythmias. J Cardiovasc Pharmacol. 1985;7 (Suppl 5):S65–S70. doi: 10.1097/00005344-198500075-00014. [DOI] [PubMed] [Google Scholar]
  15. Tarrade T., Guinot P. Efficacy and tolerance of cicletanine, a new antihypertensive agent: overview of 1226 treated patients. Drugs Exp Clin Res. 1988;14(2-3):205–214. [PubMed] [Google Scholar]
  16. Tosaki A., Hellegouarch A., Braquet P. Cicletanine and reperfusion injury: is there any correlation between arrhythmias, 6-keto-PGF1 alpha, thromboxane B2, and myocardial ion shifts (Na+, K+, Ca2+, and Mg2+) induced by ischemia/reperfusion in isolated rat heart. J Cardiovasc Pharmacol. 1991 Apr;17(4):551–559. [PubMed] [Google Scholar]
  17. Tosaki A., Koltai M., Willoughby D. A., Braquet P. Effect of cicletanine on reperfusion-induced arrhythmias and ion shifts in isolated rat hearts. J Cardiovasc Pharmacol. 1990 Feb;15(2):218–226. doi: 10.1097/00005344-199002000-00007. [DOI] [PubMed] [Google Scholar]

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