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. 1993 Feb;108(2):287–289. doi: 10.1111/j.1476-5381.1993.tb12795.x

5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.

A R Kooyman 1, J A van Hooft 1, H P Vijverberg 1
PMCID: PMC1908008  PMID: 7680589

Abstract

Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mM 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.

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Selected References

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