Abstract
The contribution of purinergic neurotransmission to bladder excitation in pigs and man is small. Exogenously-applied adenosine-trisphosphate (ATP) however, elicits large inward currents in dispersed bladder smooth muscle cells in both species. The essential properties of the ATP-induced current in human and pig detrusor are similar and the current intensity is comparable to those in the guinea-pig, which has a powerful purinergic excitatory innervation. This suggests that other features of the tissue such as the closeness of the innervation and the degree of cell-to-cell coupling may be important in determining the effectiveness of purinergic transmission.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burnstock G., Cocks T., Crowe R., Kasakov L. Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol. 1978 May;63(1):125–138. doi: 10.1111/j.1476-5381.1978.tb07782.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foster C. D., Speakman M. J., Fujii K., Brading A. F. The effects of cromakalim on the detrusor muscle of human and pig urinary bladder. Br J Urol. 1989 Mar;63(3):284–294. doi: 10.1111/j.1464-410x.1989.tb05191.x. [DOI] [PubMed] [Google Scholar]
- Fujii K. Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder. J Physiol. 1988 Oct;404:39–52. doi: 10.1113/jphysiol.1988.sp017277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoyle C. H., Chapple C., Burnstock G. Isolated human bladder: evidence for an adenine dinucleotide acting on P2X-purinoceptors and for purinergic transmission. Eur J Pharmacol. 1989 Dec 12;174(1):115–118. doi: 10.1016/0014-2999(89)90881-9. [DOI] [PubMed] [Google Scholar]
- Inoue R., Brading A. F. The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol. 1990 Jul;100(3):619–625. doi: 10.1111/j.1476-5381.1990.tb15856.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Luheshi G. N., Zar M. A. Presence of non-cholinergic motor transmission in human isolated bladder. J Pharm Pharmacol. 1990 Mar;42(3):223–224. doi: 10.1111/j.2042-7158.1990.tb05396.x. [DOI] [PubMed] [Google Scholar]
- Ruggieri M. R., Whitmore K. E., Levin R. M. Bladder purinergic receptors. J Urol. 1990 Jul;144(1):176–181. doi: 10.1016/s0022-5347(17)39405-3. [DOI] [PubMed] [Google Scholar]
- Sibley G. N. A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit. J Physiol. 1984 Sep;354:431–443. doi: 10.1113/jphysiol.1984.sp015386. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sjögren C., Andersson K. E., Husted S., Mattiasson A., Moller-Madsen B. Atropine resistance of transmurally stimulated isolated human bladder muscle. J Urol. 1982 Dec;128(6):1368–1371. doi: 10.1016/s0022-5347(17)53509-0. [DOI] [PubMed] [Google Scholar]