Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1991 Aug;103(4):1842–1846. doi: 10.1111/j.1476-5381.1991.tb12339.x

Nedocromil sodium inhibits airway hyperresponsiveness and eosinophilic infiltration induced by repeated antigen challenge in guinea-pigs.

R R Schellenberg 1, K Ishida 1, R J Thomson 1
PMCID: PMC1908185  PMID: 1655142

Abstract

1. Repeated exposure to ovalbumin aerosol produced significant increases in epithelial eosinophils of airways of all sizes and produced increased pulmonary resistance (RL) to inhaled acetylcholine (ACh) in guinea-pigs. 2. Nedocromil sodium 10 mg ml-1, by nebulization prior to each ovalbumin (OA) challenge inhibited both the airway eosinophilia and hyperresponsiveness to ACh. 3. Nedocromil sodium pretreatment (10 mg ml-1 by nebulization) 10 min prior to OA completely inhibited the acute bronchoconstrictor response to OA. 4. Our findings suggest that nedocromil sodium inhibits airway hyperresponsiveness by inhibiting eosinophilic infiltration, or by simultaneously inhibiting mechanisms involved in both processes.

Full text

PDF
1842

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham W. M., Stevenson J. S., Chapman G. A., Tallent M. W., Jackowski J. The effect of nedocromil sodium and cromolyn sodium on antigen-induced responses in allergic sheep in vivo and in vitro. Chest. 1987 Nov;92(5):913–917. doi: 10.1378/chest.92.5.913. [DOI] [PubMed] [Google Scholar]
  2. Barnes P. J. Asthma as an axon reflex. Lancet. 1986 Feb 1;1(8475):242–245. doi: 10.1016/s0140-6736(86)90777-4. [DOI] [PubMed] [Google Scholar]
  3. Bel E. H., Timmers M. C., Hermans J., Dijkman J. H., Sterk P. J. The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects. Am Rev Respir Dis. 1990 Jan;141(1):21–28. doi: 10.1164/ajrccm/141.1.21. [DOI] [PubMed] [Google Scholar]
  4. Biggs D. F., Ladenius R. C. Capsaicin selectively reduces airway responses to histamine, substance P and vagal stimulation. Eur J Pharmacol. 1990 Jan 3;175(1):29–33. doi: 10.1016/0014-2999(90)90148-y. [DOI] [PubMed] [Google Scholar]
  5. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
  6. Crimi E., Brusasco V., Brancatisano M., Losurdo E., Crimi P. Effect of nedocromil sodium on adenosine- and methacholine-induced bronchospasm in asthma. Clin Allergy. 1987 Mar;17(2):135–141. doi: 10.1111/j.1365-2222.1987.tb02331.x. [DOI] [PubMed] [Google Scholar]
  7. Crimi E., Brusasco V., Crimi P. Effect of nedocromil sodium on the late asthmatic reaction to bronchial antigen challenge. J Allergy Clin Immunol. 1989 May;83(5):985–990. doi: 10.1016/0091-6749(89)90116-4. [DOI] [PubMed] [Google Scholar]
  8. Dorward A. J., Roberts J. A., Thomson N. C. Effect of nedocromil sodium on histamine airway responsiveness in grass-pollen sensitive asthmatics during the pollen season. Clin Allergy. 1986 Jul;16(4):309–315. doi: 10.1111/j.1365-2222.1986.tb01962.x. [DOI] [PubMed] [Google Scholar]
  9. Eady R. P., Greenwood B., Jackson D. M., Orr T. S., Wells E. The effect of nedocromil sodium and sodium cromoglycate on antigen-induced bronchoconstriction in the Ascaris-sensitive monkey. Br J Pharmacol. 1985 Jun;85(2):323–325. doi: 10.1111/j.1476-5381.1985.tb08864.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Feldman H. A. Families of lines: random effects in linear regression analysis. J Appl Physiol (1985) 1988 Apr;64(4):1721–1732. doi: 10.1152/jappl.1988.64.4.1721. [DOI] [PubMed] [Google Scholar]
  11. Fuller R. W., Dixon C. M., Cuss F. M., Barnes P. J. Bradykinin-induced bronchoconstriction in humans. Mode of action. Am Rev Respir Dis. 1987 Jan;135(1):176–180. doi: 10.1164/arrd.1987.135.1.176. [DOI] [PubMed] [Google Scholar]
  12. Hulbert W. C., McLean T., Wiggs B., Paré P. D., Hogg J. C. Histamine dose-response curves in guinea pigs. J Appl Physiol (1985) 1985 Feb;58(2):625–634. doi: 10.1152/jappl.1985.58.2.625. [DOI] [PubMed] [Google Scholar]
  13. Hutson P. A., Holgate S. T., Church M. K. Inhibition by nedocromil sodium of early and late phase bronchoconstriction and airway cellular infiltration provoked by ovalbumin inhalation in conscious sensitized guinea-pigs. Br J Pharmacol. 1988 May;94(1):6–8. doi: 10.1111/j.1476-5381.1988.tb11493.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ishida K., Kelly L. J., Thomson R. J., Beattie L. L., Schellenberg R. R. Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs. J Appl Physiol (1985) 1989 Sep;67(3):1133–1139. doi: 10.1152/jappl.1989.67.3.1133. [DOI] [PubMed] [Google Scholar]
  15. James A. L., Paré P. D., Hogg J. C. Effects of lung volume, bronchoconstriction, and cigarette smoke on morphometric airway dimensions. J Appl Physiol (1985) 1988 Mar;64(3):913–919. doi: 10.1152/jappl.1988.64.3.913. [DOI] [PubMed] [Google Scholar]
  16. Joos G. F., Pauwels R. A., Van der Straeten M. E. The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. J Allergy Clin Immunol. 1989 Mar;83(3):663–668. doi: 10.1016/0091-6749(89)90080-8. [DOI] [PubMed] [Google Scholar]
  17. Lee T., Lenihan D. J., Malone B., Roddy L. L., Wasserman S. I. Increased biosynthesis of platelet-activating factor in activated human eosinophils. J Biol Chem. 1984 May 10;259(9):5526–5530. [PubMed] [Google Scholar]
  18. Nolan C. R., 3rd, Anger M. S., Kelleher S. P. Eosinophiluria--a new method of detection and definition of the clinical spectrum. N Engl J Med. 1986 Dec 11;315(24):1516–1519. doi: 10.1056/NEJM198612113152404. [DOI] [PubMed] [Google Scholar]
  19. Phillips G. D., Scott V. L., Richards R., Holgate S. T. Effect of nedocromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine 5'-monophosphate. Eur Respir J. 1989 Mar;2(3):210–217. [PubMed] [Google Scholar]
  20. Rothenberg M. E., Pomerantz J. L., Owen W. F., Jr, Avraham S., Soberman R. J., Austen K. F., Stevens R. L. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem. 1988 Sep 25;263(27):13901–13908. [PubMed] [Google Scholar]
  21. Sanderson C. J., Warren D. J., Strath M. Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures. J Exp Med. 1985 Jul 1;162(1):60–74. doi: 10.1084/jem.162.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Thomson N. C. Nedocromil sodium: an overview. Respir Med. 1989 Jul;83(4):269–276. doi: 10.1016/s0954-6111(89)80195-7. [DOI] [PubMed] [Google Scholar]
  23. Yamaguchi Y., Hayashi Y., Sugama Y., Miura Y., Kasahara T., Kitamura S., Torisu M., Mita S., Tominaga A., Takatsu K. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J Exp Med. 1988 May 1;167(5):1737–1742. doi: 10.1084/jem.167.5.1737. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES