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. 1991 Nov;104(3):714–718. doi: 10.1111/j.1476-5381.1991.tb12493.x

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre.

B Allard 1, V Jacquemond 1, F Lemtiri-Chlieh 1, B Pourrias 1, O Rougier 1
PMCID: PMC1908234  PMID: 1724630

Abstract

1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4. The action of heptaminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5. These results could be explained by a stimulation of the Na/H antiport by heptaminol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aickin C. C., Thomas R. C. An investigation of the ionic mechanism of intracellular pH regulation in mouse soleus muscle fibres. J Physiol. 1977 Dec;273(1):295–316. doi: 10.1113/jphysiol.1977.sp012095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aronson P. S. Kinetic properties of the plasma membrane Na+-H+ exchanger. Annu Rev Physiol. 1985;47:545–560. doi: 10.1146/annurev.ph.47.030185.002553. [DOI] [PubMed] [Google Scholar]
  3. Berthiau F., Garnier D., Argibay J. A., Seguin F., Pourrias B., Grivet J. P., Le Pape A. Decrease in internal H+ and positive inotropic effect of heptaminol hydrochloride: a 31P n.m.r. spectroscopy study in rat isolated heart. Br J Pharmacol. 1989 Dec;98(4):1233–1240. doi: 10.1111/j.1476-5381.1989.tb12669.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CHAUCHARD P., MAZOUE H. Heptaminol et fatigue nerveuse. C R Seances Soc Biol Fil. 1958;152(6):923–925. [PubMed] [Google Scholar]
  5. CORABOEUF E., BOISTEL J. Etude à l'aide de microélectrodes intracellulaires de l'action d'un tonicardiaque: l'amino.6-methyl.2-heptanol.2 (2831 R.P) sur le tissu nodal du coeur de chien. C R Seances Soc Biol Fil. 1953 May;147(9-10):774–779. [PubMed] [Google Scholar]
  6. Caillé J., Ildefonse M., Rougier O. Excitation-contraction coupling in skeletal muscle. Prog Biophys Mol Biol. 1985;46(3):185–239. doi: 10.1016/0079-6107(85)90009-4. [DOI] [PubMed] [Google Scholar]
  7. Caillé J., Ildefonse M., Rougier O. Existence of a sodium current in the tubular membrane of frog twitch muscle fibre; its possible role in the activation of contraction. Pflugers Arch. 1978 May 18;374(2):167–177. doi: 10.1007/BF00581298. [DOI] [PubMed] [Google Scholar]
  8. Estrada F., Sanchez J. A. The effect of amiloride on the resting potential and the electrical constants of frog skeletal muscle fibres. J Physiol. 1991 Feb;433:705–717. doi: 10.1113/jphysiol.1991.sp018451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fabiato A., Fabiato F. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. J Physiol. 1978 Mar;276:233–255. doi: 10.1113/jphysiol.1978.sp012231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haydon D. A., Urban B. W. The effects of some inhalation anaesthetics on the sodium current of the squid giant axon. J Physiol. 1983 Aug;341:429–439. doi: 10.1113/jphysiol.1983.sp014814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacquemond V., Rougier O. Nifedipine and BAY K inhibit contraction independently from their action on calcium channels. Biochem Biophys Res Commun. 1988 May 16;152(3):1002–1007. doi: 10.1016/s0006-291x(88)80383-8. [DOI] [PubMed] [Google Scholar]
  12. LOUBATIERES A., BOUYARD P., SASSINE A., MARIANI M. M. [Actions of heptaminol HCl on the cardiovascular and curarizing effects of D-tubocurarine]. C R Seances Soc Biol Fil. 1961;155:2404–2406. [PubMed] [Google Scholar]
  13. Lazdunski M., Frelin C., Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol. 1985 Nov;17(11):1029–1042. doi: 10.1016/s0022-2828(85)80119-x. [DOI] [PubMed] [Google Scholar]
  14. MUELLER P., SCHATZMANN H. J., WEIDMANN S. EFFETS DU CHLORHYDRATE D'HEPTAMINOL SUR LA CONTRACTION LE POTENTIEL D'ACTION ET LE TAUX DE POTASSIUM INTRACELLULAIRE DES FIBRES CARDIAQUES. C R Seances Soc Biol Fil. 1964;158:1850–1853. [PubMed] [Google Scholar]
  15. Moolenaar W. H., Tsien R. Y., van der Saag P. T., de Laat S. W. Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature. 1983 Aug 18;304(5927):645–648. doi: 10.1038/304645a0. [DOI] [PubMed] [Google Scholar]
  16. Nasri-Sebdani M., Cragoe E. J., Jr, Cognard C., Potreau D., Raymond G. The depressant effects of some amiloride analogues on the slow outward K+ current and contraction of voltage-clamped frog muscle fibres. Eur J Pharmacol. 1989 Nov 14;171(1):97–107. doi: 10.1016/0014-2999(89)90433-0. [DOI] [PubMed] [Google Scholar]
  17. Potreau D., Raymond G. Calcium-dependent electrical activity and contraction of voltage-clamped frog single muscle fibres. J Physiol. 1980 Oct;307:9–22. doi: 10.1113/jphysiol.1980.sp013420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Potreau D., Raymond G. Existence of a sodium-induced calcium release mechanism of frog skeletal muscle fibres. J Physiol. 1982 Dec;333:463–480. doi: 10.1113/jphysiol.1982.sp014464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Putnam R. W., Roos A., Wilding T. J. Properties of the intracellular pH-regulating systems of frog skeletal muscle. J Physiol. 1986 Dec;381:205–219. doi: 10.1113/jphysiol.1986.sp016323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Raymond G. Les mécanismes de couplage entre excitation et libération de calcium du muscle squelettique des vertébrés. Arch Int Physiol Biochim. 1989 Aug;97(4):A79–A95. doi: 10.3109/13813458909105537. [DOI] [PubMed] [Google Scholar]
  21. Rios E., Brum G. Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature. 1987 Feb 19;325(6106):717–720. doi: 10.1038/325717a0. [DOI] [PubMed] [Google Scholar]
  22. Roos A., Boron W. F. Intracellular pH. Physiol Rev. 1981 Apr;61(2):296–434. doi: 10.1152/physrev.1981.61.2.296. [DOI] [PubMed] [Google Scholar]
  23. Schneider M. F., Chandler W. K. Voltage dependent charge movement of skeletal muscle: a possible step in excitation-contraction coupling. Nature. 1973 Mar 23;242(5395):244–246. doi: 10.1038/242244a0. [DOI] [PubMed] [Google Scholar]
  24. Vassort G., Whittembury J., Mullins L. J. Increases in internal Ca2+ and decreases in internal H+ are induced by general anesthetics in squid axons. Biophys J. 1986 Jul;50(1):11–19. doi: 10.1016/S0006-3495(86)83434-8. [DOI] [PMC free article] [PubMed] [Google Scholar]

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