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. 1995 May;115(2):222–224. doi: 10.1111/j.1476-5381.1995.tb15866.x

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium.

G F Baxter 1, F M Goma 1, D M Yellon 1
PMCID: PMC1908328  PMID: 7545515

Abstract

Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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