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. 1991 Jun;103(2):1421–1428. doi: 10.1111/j.1476-5381.1991.tb09805.x

Further characterization of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasation in rat dura mater.

M G Buzzi 1, M A Moskowitz 1, S J Peroutka 1, B Byun 1
PMCID: PMC1908367  PMID: 1653072

Abstract

1. We describe the effects of pretreatment with 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on neurogenically-mediated plasma protein extravasation ([125I]-albumin) in rat dura mater and in extracranial tissues (temporalis muscle fascia, conjunctiva, eyelid and lip) induced by electrical stimulation of the right trigeminal ganglion. 2. Leakage of [125I]-bovine serum albumin from blood vessels in dura mater following high intensity stimulation (1.2 mA, 5 ms, 5 Hz for 5 min) was significantly reduced by the intravenous administration of drugs active at 5-HT receptors with some selectivity for the 5-HT1 receptor subtypes: 5-carboxamidotryptamine (5-CT) (threshold dose, 1 ng kg-1); 5-benzyloxytryptamine (5-BT) (10, 30 or 100 micrograms kg-1); 8-hydroxydipropylaminotetralin (8-OH-DPAT) (300 micrograms kg-1); and as previously reported, sumatriptan (100 micrograms kg-1), dihydroergotamine (DHE) (50 micrograms kg-1); ergotamine tartrate (100 micrograms kg-1) and chronically administered methysergide (1 mg kg-1). 3. The putative 5-HT receptor antagonist, metergoline 100 micrograms kg-1, inhibited partially the effect of sumatriptan in dura mater providing additional evidence for a 5-HT1 receptor subtype-mediated mechanism, although it was not effective against 5-CT (1 ng kg-1). Methiothepin (300 micrograms kg-1) did not affect the response to sumatriptan. When administered at high concentrations (1 mg kg-1) methiothepin and metergoline decreased plasma protein extravasation in rat dura mater.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Andres K. H., von Düring M., Muszynski K., Schmidt R. F. Nerve fibres and their terminals of the dura mater encephali of the rat. Anat Embryol (Berl) 1987;175(3):289–301. doi: 10.1007/BF00309843. [DOI] [PubMed] [Google Scholar]
  2. Bom A. H., Heiligers J. P., Saxena P. R., Verdouw P. D. Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors. Br J Pharmacol. 1989 Jun;97(2):383–390. doi: 10.1111/j.1476-5381.1989.tb11965.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bom A. H., Verdouw P. D., Saxena P. R. Carotid haemodynamics in pigs during infusions of 8-OH-DPAT: reduction in arteriovenous shunting is mediated by 5-HT1-like receptors. Br J Pharmacol. 1989 Jan;96(1):125–132. doi: 10.1111/j.1476-5381.1989.tb11792.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Buzzi M. G., Moskowitz M. A. The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br J Pharmacol. 1990 Jan;99(1):202–206. doi: 10.1111/j.1476-5381.1990.tb14679.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Buzzi M. G., Sakas D. E., Moskowitz M. A. Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater. Eur J Pharmacol. 1989 Jun 20;165(2-3):251–258. doi: 10.1016/0014-2999(89)90719-x. [DOI] [PubMed] [Google Scholar]
  6. CHAPMAN L. F., RAMOS A. O., GOODELL H., WOLFF H. G. Neurohumoral features of afferent fibers in man. Their role in vasodilation, inflammation, and pain. Arch Neurol. 1961 Jun;4:617–650. doi: 10.1001/archneur.1961.00450120031005. [DOI] [PubMed] [Google Scholar]
  7. Cline M. A., Ochoa J., Torebjörk H. E. Chronic hyperalgesia and skin warming caused by sensitized C nociceptors. Brain. 1989 Jun;112(Pt 3):621–647. doi: 10.1093/brain/112.3.621. [DOI] [PubMed] [Google Scholar]
  8. Connor H. E., Feniuk W., Humphrey P. P. Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT1-like receptor agonist. Br J Pharmacol. 1989 Feb;96(2):379–387. doi: 10.1111/j.1476-5381.1989.tb11828.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Couture R., Cuello A. C. Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat. J Physiol. 1984 Jan;346:273–285. doi: 10.1113/jphysiol.1984.sp015021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Drummond P. D., Gonski A., Lance J. W. Facial flushing after thermocoagulation of the Gasserian ganglion. J Neurol Neurosurg Psychiatry. 1983 Jul;46(7):611–616. doi: 10.1136/jnnp.46.7.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Feniuk W., Humphrey P. P., Perren M. J. The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol. 1989 Jan;96(1):83–90. doi: 10.1111/j.1476-5381.1989.tb11787.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Goadsby P. J., Edvinsson L., Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol. 1988 Feb;23(2):193–196. doi: 10.1002/ana.410230214. [DOI] [PubMed] [Google Scholar]
  13. Hardebo J. E. The involvement of trigeminal substance P neurons in cluster headache. An hypothesis. Headache. 1984 Nov;24(6):294–304. doi: 10.1111/j.1526-4610.1984.hed2406294.x. [DOI] [PubMed] [Google Scholar]
  14. Heuring R. E., Peroutka S. J. Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. J Neurosci. 1987 Mar;7(3):894–903. doi: 10.1523/JNEUROSCI.07-03-00894.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Heuring R. E., Schlegel J. R., Peroutka S. J. Species variations in RU 24969 interactions with non-5-HT1A binding sites. Eur J Pharmacol. 1986 Mar 18;122(2):279–282. doi: 10.1016/0014-2999(86)90114-7. [DOI] [PubMed] [Google Scholar]
  16. Hoyer D., Engel G., Kalkman H. O. Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol. Eur J Pharmacol. 1985 Nov 26;118(1-2):1–12. doi: 10.1016/0014-2999(85)90657-0. [DOI] [PubMed] [Google Scholar]
  17. Hoyer D., Middlemiss D. N. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol Sci. 1989 Apr;10(4):130–132. doi: 10.1016/0165-6147(89)90159-4. [DOI] [PubMed] [Google Scholar]
  18. Hoyer D., Pazos A., Probst A., Palacios J. M. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res. 1986 Jun 18;376(1):85–96. doi: 10.1016/0006-8993(86)90902-9. [DOI] [PubMed] [Google Scholar]
  19. Humphrey P. P., Feniuk W., Perren M. J., Connor H. E., Oxford A. W., Coates L. H., Butina D. GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein. Br J Pharmacol. 1988 Aug;94(4):1123–1132. doi: 10.1111/j.1476-5381.1988.tb11630.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Jancsó-Gábor A., Szolcsányi J. Neurogenic inflammatory responses. J Dent Res. 1972 Mar-Apr;51(2):264–269. doi: 10.1177/00220345720510020901. [DOI] [PubMed] [Google Scholar]
  21. Markowitz S., Saito K., Moskowitz M. A. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci. 1987 Dec;7(12):4129–4136. doi: 10.1523/JNEUROSCI.07-12-04129.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Moskowitz M. A., Reinhard J. F., Jr, Romero J., Melamed E., Pettibone D. J. Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Lancet. 1979 Oct 27;2(8148):883–885. doi: 10.1016/s0140-6736(79)92692-8. [DOI] [PubMed] [Google Scholar]
  23. Moskowitz M. A. The neurobiology of vascular head pain. Ann Neurol. 1984 Aug;16(2):157–168. doi: 10.1002/ana.410160202. [DOI] [PubMed] [Google Scholar]
  24. Murphy T. J., Bylund D. B. Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line. J Pharmacol Exp Ther. 1988 Feb;244(2):571–578. [PubMed] [Google Scholar]
  25. Offord S. J., Ordway G. A., Frazer A. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. J Pharmacol Exp Ther. 1988 Jan;244(1):144–153. [PubMed] [Google Scholar]
  26. Perney T. M., Hirning L. D., Leeman S. E., Miller R. J. Multiple calcium channels mediate neurotransmitter release from peripheral neurons. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6656–6659. doi: 10.1073/pnas.83.17.6656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Perren M. J., Feniuk W., Humphrey P. P. The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175. Cephalalgia. 1989;9 (Suppl 9):41–46. doi: 10.1111/J.1468-2982.1989.TB00071.X. [DOI] [PubMed] [Google Scholar]
  28. Saito K., Markowitz S., Moskowitz M. A. Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches. Ann Neurol. 1988 Dec;24(6):732–737. doi: 10.1002/ana.410240607. [DOI] [PubMed] [Google Scholar]
  29. Saxena P. R. Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect. Eur J Pharmacol. 1974 Jun;27(1):99–105. doi: 10.1016/0014-2999(74)90206-4. [DOI] [PubMed] [Google Scholar]
  30. Saxena P. R., Verdouw P. D. 5-Carboxamide tryptamine, a compound with high affinity for 5-hydroxytryptamine1 binding sites, dilates arterioles and constricts arteriovenous anastomoses. Br J Pharmacol. 1985 Feb;84(2):533–544. doi: 10.1111/j.1476-5381.1985.tb12938.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Schlicker E., Fink K., Göthert M., Hoyer D., Molderings G., Roschke I., Schoeffter P. The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):45–51. doi: 10.1007/BF00169206. [DOI] [PubMed] [Google Scholar]
  32. Sweet W. H., Wepsic J. G. Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers. 1. Trigeminal neuralgia. J Neurosurg. 1974 Feb;40(2):143–156. doi: 10.3171/jns.1974.40.2.0143. [DOI] [PubMed] [Google Scholar]
  33. Waeber C., Schoeffter P., Palacios J. M., Hoyer D. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):595–601. doi: 10.1007/BF00175783. [DOI] [PubMed] [Google Scholar]

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